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Overview

Uniprot ID	Q9TV36
Protein Name	Fibrillin-1
Gene Name	FBN1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
2069	YAKFEGGKCSSPKSR
2360	SNRNPVTKSECCCDG
54	GGGHDALKGPNVCGS
799	CPKGFIYKPDLKTCE

Function

Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils

Protein Sequence

10 MRRGRLLEVA 20 LGFTVLLASY 30 TSHRAEANLE 40 AGNGKETRAS 50 RAKRRGGGGH 60 DALKGPNVCG 70 SRYNAYCCPG 80 WKTLPGGNQC 90 IVPICRHSCG 100 DGFCSRPNMC 110 TCPSGQIAPS 120 CGSRSIQHCN 130 IRCMNGGSCS 140 DDHCLCQKGY 150 IGTHCGQPVC 160 ESGCLNGGRC 170 VAPNRCACTY 180 GFTGPQCERD 190 YRTGPCFTVV 200 SNQMCQGQLS 210 GIVCTKTLCC 220 ATVGRAWGHP 230 CEMCPAQPHP 240 CRRGFIPNIR 250 TGACQDVDEC 260 QAIPGLCQGG 270 NCINTVGSFE 280 CKCPAGHKFN 290 EVSQKCEDID 300 ECSTIPGICD 310 GGECTNTVSS 320 YFCKCPPGFY 330 TSPDGTRCID 340 VRPGYCYTAL 350 TNGRCSNQLP 360 QSITKMQCCC 370 DVGRCWSPGV 380 TVTPEMCPIR 390 ATEDFNKLCS 400 VPMVVPERPG 410 YPSPPLGPIP 420 PVHPVPPGFP 430 PGPQIPVPRP 440 PVEYPYPSRE 450 PPRVLPVNVT 460 DYCQLFRYLC 470 HNGRCIPTPG 480 SYRCECNKGF 490 QLDLRGECID 500 VDECEKNPCA 510 GGECINNQGS 520 YTCQCRPGYQ 530 STLTRTECRD 540 IDECLQNGRI 550 CNNGRCINTD 560 GSFHCVCNAG 570 FHVTRDGKNC 580 EDMDECSIRN 590 MCLNGMCINE 600 DGSFKCICKP 610 GFQLASDGRY 620 CKDINECETS 630 GICMNGRCVN 640 TDGSYRCECF 650 PGLAVGLDGR 660 VCVDTHMRST 670 CYGGYKRGQC 680 VKPLFGAVTK 690 SECCCASTEY 700 AFGEPCQPCP 710 SQNSAEYQAL 720 CSSGPGMTSA 730 GSDINECALD 740 PDICPNGICE 750 NLRGTYKCIC 760 NSGYEVDSTG 770 KNCVDINECV 780 LNSLLCDNGQ 790 CRNTPGSFVC 800 TCPKGFIYKP 810 DLKTCEDIDE 820 CESSPCINGV 830 CKNSPGSFIC 840 ECSSESTLDP 850 TKTICIETIK 860 GTCWQTIIDG 870 RCEININGAT 880 LKSQCCSSLG 890 AAWGSPCTPC 900 QVDPICGKGY 910 SRIKGTQCED 920 IDECEVFPGV 930 CKNGLCVNSK 940 GSFKCQCPNG 950 MTLDATGRIC 960 LDIRLETCFL 970 RYEDEECTLP 980 VVGRHRMDAC 990 CCSVGAAWGT 1000 EECEECPPRN 1010 TPEYEELCPR 1020 GPGFATKEIT 1030 NGKPFFKDIN 1040 ECKMIPNLCT 1050 HGKCRNTIGS 1060 FKCRCDSGFA 1070 LDSEERNCID 1080 IDECRISPDL 1090 CGRGQCVNTP 1100 GDFECKCDEG 1110 YESGFMMMKN 1120 CMDIDECQRD 1130 PLLCRGGVCL 1140 NTEGSYRCEC 1150 PSGHQMSPNI 1160 SACIDINECE 1170 LSAHLCPHGR 1180 CVNLIGKYQR 1190 ARNPGYHSTP 1200 DRLFCVDIDE 1210 CSIMNGGCET 1220 FCTNSEGSYE 1230 CSCQPGFALM 1240 PDQRSCTDID 1250 ECEDNPNICD 1260 GGQCTNIPGE 1270 YRCLCYDGFM 1280 ASEDMKTCVD 1290 VNECDLNPNI 1300 CLSGTCENTK 1310 GSFICHCDMG 1320 YSGKKGKTGC 1330 TDINECEIGA 1340 HNCDRHAVCT 1350 NTAGSFNCSC 1360 SPGWIGDGIK 1370 CTDLDECSNG 1380 THMCSQHADC 1390 KNTMGSYRCL 1400 CKEGYTGDGF 1410 TCADLDECSE 1420 NVKLCGNVQC 1430 LYAPGGYHCE 1440 YDMGFVPSAD 1450 RKSCVDSDEC 1460 SLPNICVFGT 1470 CHNLPGLFRC 1480 ECEIGYELDR 1490 SGGNCTDVNE 1500 CLEPPTCISG 1510 NCVNTPGSYT 1520 CVCPPDFELN 1530 PTRVGCVDTR 1540 SGNCYLDVRP 1550 RGDNGDTACS 1560 NEIGVGVSKA 1570 SCCCSLGKAW 1580 GTPCEQCPPV 1590 NTSEYKILCP 1600 GGEGFRPNPI 1610 TVILEDIDEC 1620 QELPGLCQGG 1630 KCINTFGSFQ 1640 CRCPTGYYLN 1650 EDTRVCDDVN 1660 ECETPGICGP 1670 GTCYNTVGNY 1680 TCICPPDYMQ 1690 VNGGNNCMDM 1700 RRSLCYRNYY 1710 ADNQTCDGEL 1720 LFNMTKKMCC 1730 CSYNIGRAWN 1740 KPCEQCPIPS 1750 TDEFATLCGS 1760 QRPGFVIDIY 1770 TGLPVDIDEC 1780 REIPGVCENG 1790 VCINMVGSFR 1800 CECPVGFFYN 1810 DKLLVCEDID 1820 ECQNGPVCQR 1830 NAECINTAGS 1840 YRCDCKPGYR 1850 FTSTGQCNDR 1860 NECQEIPNIC 1870 SHGQCIDTVG 1880 SFYCLCHTGF 1890 KTNADQTMCL 1900 DINECERDAC 1910 GNGTCRNTIG 1920 SFNCRCNHGF 1930 ILSHNNDCID 1940 VDECATGNGN 1950 LCRNGQCINT 1960 VGSFQCQCNE 1970 GYEVAPDGRT 1980 CVDINECLLE 1990 PGKCAPGTCQ 2000 NLDGSYRCIC 2010 PPGYSLQNDK 2020 CEDIDECVEE 2030 PEICALGTCS 2040 NTEGSFKCLC 2050 PDGFSLSSTG 2060 RRCQDLRMSY 2070 CYAKFEGGKC 2080 SSPKSRNHSK 2090 QECCCALKGE 2100 GWGDPCELCP 2110 TEPDEAFRQI 2120 CPYGSGIIVG 2130 PDDSAVDMDE 2140 CKEPDVCKHG 2150 QCINTDGSYR 2160 CECPFGYILE 2170 GNECVDTDEC 2180 SVGNPCGNGT 2190 CKNVIGGFEC 2200 TCEEGFEPGP 2210 MMTCEDINEC 2220 AQNPLLCAFR 2230 CVNTYGSYEC 2240 KCPTGYVLRE 2250 DRRMCKDEDE 2260 CEEGKHDCAE 2270 KQMECKNLIG 2280 MYICICGPGY 2290 QRRPDGEGCV 2300 DENECQTKPG 2310 ICENGRCLNT 2320 RGSYTCECND 2330 GFTASPTQDE 2340 CLDNREGYCF 2350 TEVLQNMCQI 2360 GSSNRNPVTK 2370 SECCCDGGRG 2380 WGPHCEICPF 2390 QGTVAFKKLC 2400 PHGRGFMTNG 2410 ADIDECKVIH 2420 DVCRNGECIN 2430 DRGSYHCICK 2440 TGYTPDITGT 2450 ACVDLNECNQ 2460 APKPCNFICK 2470 NTEGSYQCSC 2480 PKGYILQEDG 2490 RSCKDLDECA 2500 TKQHNCQFLC 2510 VNTIGSFACK 2520 CPPGFTQHHT 2530 ACIDNNECTS 2540 DINLCGAKGI 2550 CQNTPGSFTC 2560 ECQRGFSLDQ 2570 SGASCEDVDE 2580 CEGNHRCQHG 2590 CQNIIGGYRC 2600 SCPQGYLQHY 2610 QWNQCVDENE 2620 CLSAHICGGA 2630 SCHNTLGSYK 2640 CMCPAGFQYE 2650 QFSGGCQDIN 2660 ECGSSQAPCS 2670 YGCSNTEGGY 2680 LCGCPPGYFR 2690 IGQGHCVSGM 2700 GMGRGSPEPP 2710 ASGEMDDNSL 2720 SPEACYECKI 2730 NGYPKRGRKR 2740 RSTNETDAFN 2750 IEDQPETESN 2760 VSLASWDVEK 2770 TAVFAFNISH 2780 ISNKVRILEL 2790 LPALTTLTNH 2800 NRYLIESGNE 2810 NGFFKINQKE 2820 GISYLHFTKK 2830 KPVAGTYSLQ 2840 ISSTPLYKKK 2850 ELNQLEDKYD 2860 KDYLSGELGD 2870 NLKMKIQILL H

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0001527	microfibril
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0005201	extracellular matrix structural constituent
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0005179	hormone activity
Biological Process	GO:0042593	glucose homeostasis
Biological Process	GO:0006006	glucose metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.