Search Results

Overview

Uniprot IDQ9UBB6
Protein NameNeurochondrin
Gene NameNCDN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
272 LARILGSKLSSWQRN
92 PNRLLTTKEAPDGCP

Function

Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable)

Protein Sequence

10 MSCCDLAAAG 20 QLGKASIMAS 30 DCEPALNQAE 40 GRNPTLERYL 50 GALREAKNDS 60 EQFAALLLVT 70 KAVKAGDIDA 80 KTRRRIFDAV 90 GFTFPNRLLT 100 TKEAPDGCPD 110 HVLRALGVAL 120 LACFCSDPEL 130 AAHPQVLNKI 140 PILSTFLTAR 150 GDPDDAARRS 160 MIDDTYQCLT 170 AVAGTPRGPR 180 HLIAGGTVSA 190 LCQAYLGHGY 200 GFDQALALLV 210 GLLAAAETQC 220 WKEAEPDLLA 230 VLRGLSEDFQ 240 KAEDASKFEL 250 CQLLPLFLPP 260 TTVPPECYRD 270 LQAGLARILG 280 SKLSSWQRNP 290 ALKLAARLAH 300 ACGSDWIPAG 310 SSGSKFLALL 320 VNLACVEVRL 330 ALEETGTEVK 340 EDVVTACYAL 350 MELGIQECTR 360 CEQSLLKEPQ 370 KVQLVSVMKE 380 AIGAVIHYLL 390 QVGSEKQKEP 400 FVFASVRILG 410 AWLAEETSSL 420 RKEVCQLLPF 430 LVRYAKTLYE 440 EAEEANDLSQ 450 QVANLAISPT 460 TPGPTWPGDA 470 LRLLLPGWCH 480 LTVEDGPREI 490 LIKEGAPSLL 500 CKYFLQQWEL 510 TSPGHDTSVL 520 PDSVEIGLQT 530 CCHIFLNLVV 540 TAPGLIKRDA 550 CFTSLMNTLM 560 TSLPALVQQQ 570 GRLLLAANVA 580 TLGLLMARLL 590 STSPALQGTP 600 ASRGFFAAAI 610 LFLSQSHVAR 620 ATPGSDQAVL 630 ALSPEYEGIW 640 ADLQELWFLG 650 MQAFTGCVPL 660 LPWLAPAALR 670 SRWPQELLQL 680 LGSVSPNSVK 690 PEMVAAYQGV 700 LVELARANRL 710 CREAMRLQAG 720 EETASHYRMA ALEQCLSEP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0098794 postsynapse
Biological Process GO:0031175 neuron projection development
Biological Process GO:0048168 regulation of neuronal synaptic plasticity
Biological Process GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.