Search Results

Overview

Uniprot IDQ9UBB9
Protein NameTuftelin-interacting protein 11
Gene NameTFIP11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
120 DFGPRKLKTGGNFKP
155 HTKGIGQKLLQKMGY
159 IGQKLLQKMGYVPGR
170 VPGRGLGKNAQGIIN
182 IINPIEAKQRKGKGA
187 EAKQRKGKGAVGAYG
241 KKPKYSYKTVEELKA
249 TVEELKAKGRISKKL
255 AKGRISKKLTAPQKE
261 KKLTAPQKELSQVKV
741 LTHTERRKDFQYEAM
794 VFMPVIGKRHEGKQL
86 NFISAGLKKGAAEEA

Function

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix

Protein Sequence

10 MSLSHLYRDG 20 EGRIDDDDDE 30 RENFEITDWD 40 LQNEFNPNRQ 50 RHWQTKEEAT 60 YGVWAERDSD 70 DERPSFGGKR 80 ARDYSAPVNF 90 ISAGLKKGAA 100 EEAELEDSDD 110 EEKPVKQDDF 120 PKDFGPRKLK 130 TGGNFKPSQK 140 GFAGGTKSFM 150 DFGSWERHTK 160 GIGQKLLQKM 170 GYVPGRGLGK 180 NAQGIINPIE 190 AKQRKGKGAV 200 GAYGSERTTQ 210 SMQDFPVVDS 220 EEEAEEEFQK 230 ELSQWRKDPS 240 GSKKKPKYSY 250 KTVEELKAKG 260 RISKKLTAPQ 270 KELSQVKVID 280 MTGREQKVYY 290 SYSQISHKHN 300 VPDDGLPLQS 310 QQLPQSGKEA 320 KAPGFALPEL 330 EHNLQLLIDL 340 TEQEIIQNDR 350 QLQYERDMVV 360 NLFHELEKMT 370 EVLDHEERVI 380 SNLSKVLEMV 390 EECERRMQPD 400 CSNPLTLDEC 410 ARIFETLQDK 420 YYEEYRMSDR 430 VDLAVAIVYP 440 LMKEYFKEWD 450 PLKDCTYGTE 460 IISKWKSLLE 470 NDQLLSHGGQ 480 DLSADAFHRL 490 IWEVWMPFVR 500 NIVTQWQPRN 510 CDPMVDFLDS 520 WVHIIPVWIL 530 DNILDQLIFP 540 KLQKEVENWN 550 PLTDTVPIHS 560 WIHPWLPLMQ 570 ARLEPLYSPI 580 RSKLSSALQK 590 WHPSDSSAKL 600 ILQPWKDVFT 610 PGSWEAFMVK 620 NIVPKLGMCL 630 GELVINPHQQ 640 HMDAFYWVID 650 WEGMISVSSL 660 VGLLEKHFFP 670 KWLQVLCSWL 680 SNSPNYEEIT 690 KWYLGWKSMF 700 SDQVLAHPSV 710 KDKFNEALDI 720 MNRAVSSNVG 730 AYMQPGAREN 740 IAYLTHTERR 750 KDFQYEAMQE 760 RREAENMAQR 770 GIGVAASSVP 780 MNFKDLIETK 790 AEEHNIVFMP 800 VIGKRHEGKQ 810 LYTFGRIVIY 820 IDRGVVFVQG 830 EKTWVPTSLQ SLIDMAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005681 spliceosomal complex
Cellular Component GO:0071008 U2-type post-mRNA release spliceosomal complex
Molecular Function GO:0003676 nucleic acid binding
Biological Process GO:0031214 biomineral tissue development
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:0031848 protection from non-homologous end joining at telomere
Biological Process GO:0006396 RNA processing
Biological Process GO:0000390 spliceosomal complex disassembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.