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Overview

Uniprot IDQ9UBC2
Protein NameEpidermal growth factor receptor substrate 15-like 1
Gene NameEPS15L1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
546 EINQARSKLSQLHES
701 KNPSLPSKLDPFESS

Function

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2

Protein Sequence

10 MAAPLIPLSQ 20 QIPTGNSLYE 30 SYYKQVDPAY 40 TGRVGASEAA 50 LFLKKSGLSD 60 IILGKIWDLA 70 DPEGKGFLDK 80 QGFYVALRLV 90 ACAQSGHEVT 100 LSNLNLSMPP 110 PKFHDTSSPL 120 MVTPPSAEAH 130 WAVRVEEKAK 140 FDGIFESLLP 150 INGLLSGDKV 160 KPVLMNSKLP 170 LDVLGRVWDL 180 SDIDKDGHLD 190 RDEFAVAMHL 200 VYRALEKEPV 210 PSALPPSLIP 220 PSKRKKTVFP 230 GAVPVLPASP 240 PPKDSLRSTP 250 SHGSVSSLNS 260 TGSLSPKHSL 270 KQTQPTVNWV 280 VPVADKMRFD 290 EIFLKTDLDL 300 DGYVSGQEVK 310 EIFMHSGLTQ 320 NLLAHIWALA 330 DTRQTGKLSK 340 DQFALAMYFI 350 QQKVSKGIDP 360 PQVLSPDMVP 370 PSERGTPGPD 380 SSGSLGSGEF 390 TGVKELDDIS 400 QEIAQLQREK 410 YSLEQDIREK 420 EEAIRQKTSE 430 VQELQNDLDR 440 ETSSLQELEA 450 QKQDAQDRLD 460 EMDQQKAKLR 470 DMLSDVRQKC 480 QDETQMISSL 490 KTQIQSQESD 500 LKSQEDDLNR 510 AKSELNRLQQ 520 EETQLEQSIQ 530 AGRVQLETII 540 KSLKSTQDEI 550 NQARSKLSQL 560 HESRQEAHRS 570 LEQYDQVLDG 580 AHGASLTDLA 590 NLSEGVSLAE 600 RGSFGAMDDP 610 FKNKALLFSN 620 NTQELHPDPF 630 QTEDPFKSDP 640 FKGADPFKGD 650 PFQNDPFAEQ 660 QTTSTDPFGG 670 DPFKESDPFR 680 GSATDDFFKK 690 QTKNDPFTSD 700 PFTKNPSLPS 710 KLDPFESSDP 720 FSSSSVSSKG 730 SDPFGTLDPF 740 GSGSFNSAEG 750 FADFSQMSKP 760 PPSGPFTSSL 770 GGAGFSDDPF 780 KSKQDTPALP 790 PKKPAPPRPK 800 PPSGKSTPVS 810 QLGSADFPEA 820 PDPFQPLGAD 830 SGDPFQSKKG 840 FGDPFSGKDP 850 FVPSSAAKPS 860 KASASGFADF TSVS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030132 clathrin coat of coated pit
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098793 presynapse
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0006897 endocytosis
Biological Process GO:0016197 endosomal transport
Biological Process GO:0048488 synaptic vesicle endocytosis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.