Search Results

Overview

Uniprot IDQ9UBD5
Protein NameOrigin recognition complex subunit 3
Gene NameORC3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
165 CCVDIKSKEEESVHV
21 KPNSKKRKISLPIED
523 SQPKGLQKTDLYHLQ
531 TDLYHLQKSLLEMKE
96 RDLGGQIKLREIPTA

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3

Protein Sequence

10 MATSSMSKGC 20 FVFKPNSKKR 30 KISLPIEDYF 40 NKGKNEPEDS 50 KLRFETYQLI 60 WQQMKSENER 70 LQEELNKNLF 80 DNLIEFLQKS 90 HSGFQKNSRD 100 LGGQIKLREI 110 PTAALVLGVN 120 VTDHDLTFGS 130 LTEALQNNVT 140 PYVVSLQAKD 150 CPDMKHFLQK 160 LISQLMDCCV 170 DIKSKEEESV 180 HVTQRKTHYS 190 MDSLSSWYMT 200 VTQKTDPKML 210 SKKRTTSSQW 220 QSPPVVVILK 230 DMESFATKVL 240 QDFIIISSQH 250 LHEFPLILIF 260 GIATSPIIIH 270 RLLPHAVSSL 280 LCIELFQSLS 290 CKEHLTTVLD 300 KLLLTTQFPF 310 KINEKVLQVL 320 TNIFLYHDFS 330 VQNFIKGLQL 340 SLLEHFYSQP 350 LSVLCCNLPE 360 AKRRINFLSN 370 NQCENIRRLP 380 SFRRYVEKQA 390 SEKQVALLTN 400 ERYLKEETQL 410 LLENLHVYHM 420 NYFLVLRCLH 430 KFTSSLPKYP 440 LGRQIRELYC 450 TCLEKNIWDS 460 EEYASVLQLL 470 RMLAKDELMT 480 ILEKCFKVFK 490 SYCENHLGST 500 AKRIEEFLAQ 510 FQSLDETKEE 520 EDASGSQPKG 530 LQKTDLYHLQ 540 KSLLEMKELR 550 RSKKQTKFEV 560 LRENVVNFID 570 CLVREYLLPP 580 ETQPLHEVVY 590 FSAAHALREH 600 LNAAPRIALH 610 TALNNPYYYL 620 KNEALKSEEG 630 CIPNIAPDIC 640 IAYKLHLECS 650 RLINLVDWSE 660 AFATVVTAAE 670 KMDANSATSE 680 EMNEIIHARF 690 IRAVSELELL 700 GFIKPTKQKT 710 DHVARLTWGG C

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0031261 DNA replication preinitiation complex
Cellular Component GO:0005664 nuclear origin of replication recognition complex
Cellular Component GO:0005656 nuclear pre-replicative complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000808 origin recognition complex
Molecular Function GO:0003688 DNA replication origin binding
Biological Process GO:0006260 DNA replication
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0006275 regulation of DNA replication

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.