Overview
| Uniprot ID | Q9UBF2 |
|---|
| Protein Name | Coatomer subunit gamma-2 |
|---|
| Gene Name | COPG2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 300 |
QLFCSSPKPALRYAA |
| 602 |
LVATKPEKLAPSRQD |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)
Protein Sequence
10
MIKKFDKKDE
20
ESGSGSNPFQ
30
HLEKSAVLQE
40
ARIFNETPIN
50
PRRCLHILTK
60
ILYLLNQGEH
70
FGTTEATEAF
80
FAMTRLFQSN
90
DQTLRRMCYL
100
TIKEMATISE
110
DVIIVTSSLT
120
KDMTGKEDVY
130
RGPAIRALCR
140
ITDGTMLQAI
150
ERYMKQAIVD
160
KVSSVSSSAL
170
VSSLHMMKIS
180
YDVVKRWINE
190
AQEAASSDNI
200
MVQYHALGVL
210
YHLRKNDRLA
220
VSKMLNKFTK
230
SGLKSQFAYC
240
MLIRIASRLL
250
KETEDGHESP
260
LFDFIESCLR
270
NKHEMVIYEA
280
ASAIIHLPNC
290
TARELAPAVS
300
VLQLFCSSPK
310
PALRYAAVRT
320
LNKVAMKHPS
330
AVTACNLDLE
340
NLITDSNRSI
350
ATLAITTLLK
360
TGSESSVDRL
370
MKQISSFVSE
380
ISDEFKVVVV
390
QAISALCQKY
400
PRKHSVMMTF
410
LSNMLRDDGG
420
FEYKRAIVDC
430
IISIVEENPE
440
SKEAGLAHLC
450
EFIEDCEHTV
460
LATKILHLLG
470
KEGPRTPVPS
480
KYIRFIFNRV
490
VLENEAVRAA
500
AVSALAKFGA
510
QNESLLPSIL
520
VLLQRCMMDT
530
DDEVRDRATF
540
YLNVLQQRQM
550
ALNATYIFNG
560
LTVSVPGMEK
570
ALHQYTLEPS
580
EKPFDMKSIP
590
LAMAPVFEQK
600
AEITLVATKP
610
EKLAPSRQDI
620
FQEQLAAIPE
630
FLNIGPLFKS
640
SEPVQLTEAE
650
TEYFVRCIKH
660
MFTNHIVFQF
670
DCTNTLNDQL
680
LEKVTVQMEP
690
SDSYEVLSCI
700
PAPSLPYNQP
710
GICYTLVRLP
720
DDDPTAVAGS
730
FSCTMKFTVR
740
DCDPNTGVPD
750
EDGYDDEYVL
760
EDLEVTVSDH
770
IQKVLKPNFA
780
AAWEEVGDTF
790
EKEETFALSS
800
TKTLEEAVNN
810
IITFLGMQPC
820
ERSDKVPENK
830
NSHSLYLAGI
840
FRGGYDLLVR
850
SRLALADGVT
860
MQVTVRSKER
870
TPVDVILASV
G
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030126 |
COPI vesicle coat |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005793 |
endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0030426 |
growth cone |
| Cellular Component |
GO:0030133 |
transport vesicle |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0006891 |
intra-Golgi vesicle-mediated transport |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0072384 |
organelle transport along microtubule |
| Biological Process |
GO:0009306 |
protein secretion |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.