Overview
| Uniprot ID | Q9UBJ2 |
|---|
| Protein Name | ATP-binding cassette sub-family D member 2 |
|---|
| Gene Name | ABCD2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 614 |
DVLSGGEKQRMGMAR |
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transported in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed:29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21145416)
Protein Sequence
10
MTHMLNAAAD
20
RVKWTRSSAA
30
KRAACLVAAA
40
YALKTLYPII
50
GKRLKQSGHG
60
KKKAAAYPAA
70
ENTEILHCTE
80
TICEKPSPGV
90
NADFFKQLLE
100
LRKILFPKLV
110
TTETGWLCLH
120
SVALISRTFL
130
SIYVAGLDGK
140
IVKSIVEKKP
150
RTFIIKLIKW
160
LMIAIPATFV
170
NSAIRYLECK
180
LALAFRTRLV
190
DHAYETYFTN
200
QTYYKVINMD
210
GRLANPDQSL
220
TEDIMMFSQS
230
VAHLYSNLTK
240
PILDVMLTSY
250
TLIQTATSRG
260
ASPIGPTLLA
270
GLVVYATAKV
280
LKACSPKFGK
290
LVAEEAHRKG
300
YLRYVHSRII
310
ANVEEIAFYR
320
GHKVEMKQLQ
330
KSYKALADQM
340
NLILSKRLWY
350
IMIEQFLMKY
360
VWSSSGLIMV
370
AIPIITATGF
380
ADGEDGQKQV
390
MVSERTEAFT
400
TARNLLASGA
410
DAIERIMSSY
420
KEVTELAGYT
430
ARVYNMFWVF
440
DEVKRGIYKR
450
TAVIQESESH
460
SKNGAKVELP
470
LSDTLAIKGK
480
VIDVDHGIIC
490
ENVPIITPAG
500
EVVASRLNFK
510
VEEGMHLLIT
520
GPNGCGKSSL
530
FRILSGLWPV
540
YEGVLYKPPP
550
QHMFYIPQRP
560
YMSLGSLRDQ
570
VIYPDSVDDM
580
HDKGYTDQDL
590
ERILHNVHLY
600
HIVQREGGWD
610
AVMDWKDVLS
620
GGEKQRMGMA
630
RMFYHKPKYA
640
LLDECTSAVS
650
IDVEGKIFQA
660
AKGAGISLLS
670
ITHRPSLWKY
680
HTHLLQFDGE
690
GGWRFEQLDT
700
AIRLTLSEEK
710
QKLESQLAGI
720
PKMQQRLNEL
730
CKILGEDSVL
740
KTIKNEDETS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005778 |
peroxisomal membrane |
| Cellular Component |
GO:0005777 |
peroxisome |
| Molecular Function |
GO:0140359 |
ABC-type transporter activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0042626 |
ATPase-coupled transmembrane transporter activity |
| Molecular Function |
GO:0047617 |
fatty acyl-CoA hydrolase activity |
| Molecular Function |
GO:0005324 |
long-chain fatty acid transmembrane transporter activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0006635 |
fatty acid beta-oxidation |
| Biological Process |
GO:0006633 |
fatty acid biosynthetic process |
| Biological Process |
GO:0015910 |
long-chain fatty acid import into peroxisome |
| Biological Process |
GO:0043217 |
myelin maintenance |
| Biological Process |
GO:1900016 |
negative regulation of cytokine production involved in inflammatory response |
| Biological Process |
GO:1903427 |
negative regulation of reactive oxygen species biosynthetic process |
| Biological Process |
GO:1990535 |
neuron projection maintenance |
| Biological Process |
GO:0007031 |
peroxisome organization |
| Biological Process |
GO:0032000 |
positive regulation of fatty acid beta-oxidation |
| Biological Process |
GO:2001280 |
positive regulation of unsaturated fatty acid biosynthetic process |
| Biological Process |
GO:0042760 |
very long-chain fatty acid catabolic process |
| Biological Process |
GO:0000038 |
very long-chain fatty acid metabolic process |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.