Overview
| Uniprot ID | Q9UBL3 |
|---|
| Protein Name | Set1/Ash2 histone methyltransferase complex subunit ASH2 |
|---|
| Gene Name | ASH2L |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 216 |
TTRQRPGKMTWPNNI |
| 294 |
IAAGSSGKGRGAKRK |
| 312 |
GGTTGTTKKARSDPL |
Function
Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653)
Protein Sequence
10
MAAAGAGPGQ
20
EAGAGPGPGA
30
VANATGAEEG
40
EMKPVAAGAA
50
APPGEGISAA
60
PTVEPSSGEA
70
EGGEANLVDV
80
SGGLETESSN
90
GKDTLEGAGD
100
TSEVMDTQAG
110
SVDEENGRQL
120
GEVELQCGIC
130
TKWFTADTFG
140
IDTSSCLPFM
150
TNYSFHCNVC
160
HHSGNTYFLR
170
KQANLKEMCL
180
SALANLTWQS
190
RTQDEHPKTM
200
FSKDKDIIPF
210
IDKYWECMTT
220
RQRPGKMTWP
230
NNIVKTMSKE
240
RDVFLVKEHP
250
DPGSKDPEED
260
YPKFGLLDQD
270
LSNIGPAYDN
280
QKQSSAVSTS
290
GNLNGGIAAG
300
SSGKGRGAKR
310
KQQDGGTTGT
320
TKKARSDPLF
330
SAQRLPPHGY
340
PLEHPFNKDG
350
YRYILAEPDP
360
HAPDPEKLEL
370
DCWAGKPIPG
380
DLYRACLYER
390
VLLALHDRAP
400
QLKISDDRLT
410
VVGEKGYSMV
420
RASHGVRKGA
430
WYFEITVDEM
440
PPDTAARLGW
450
SQPLGNLQAP
460
LGYDKFSYSW
470
RSKKGTKFHQ
480
SIGKHYSSGY
490
GQGDVLGFYI
500
NLPEDTETAK
510
SLPDTYKDKA
520
LIKFKSYLYF
530
EEKDFVDKAE
540
KSLKQTPHSE
550
IIFYKNGVNQ
560
GVAYKDIFEG
570
VYFPAISLYK
580
SCTVSINFGP
590
CFKYPPKDLT
600
YRPMSDMGWG
610
AVVEHTLADV
620
LYHVETEVDG
RRSPPWEP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0035097 |
histone methyltransferase complex |
| Cellular Component |
GO:0071339 |
MLL1 complex |
| Cellular Component |
GO:0044666 |
MLL3/4 complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0048188 |
Set1C/COMPASS complex |
| Molecular Function |
GO:0008013 |
beta-catenin binding |
| Molecular Function |
GO:0000976 |
transcription cis-regulatory region binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0030097 |
hemopoiesis |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0043627 |
response to estrogen |
| Biological Process |
GO:0045815 |
transcription initiation-coupled chromatin remodeling |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.