Search Results

Overview

Uniprot ID	Q9UBM7
Protein Name	7-dehydrocholesterol reductase
Gene Name	DHCR7
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
13	QPNIPKAKSLDGVTN

Function

Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (PubMed:25637936, PubMed:38297129, PubMed:38297130, PubMed:9465114, PubMed:9634533). Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (By similarity). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation (PubMed:38297129, PubMed:38297130)

Protein Sequence

10 MAAKSQPNIP 20 KAKSLDGVTN 30 DRTASQGQWG 40 RAWEVDWFSL 50 ASVIFLLLFA 60 PFIVYYFIMA 70 CDQYSCALTG 80 PVVDIVTGHA 90 RLSDIWAKTP 100 PITRKAAQLY 110 TLWVTFQVLL 120 YTSLPDFCHK 130 FLPGYVGGIQ 140 EGAVTPAGVV 150 NKYQINGLQA 160 WLLTHLLWFA 170 NAHLLSWFSP 180 TIIFDNWIPL 190 LWCANILGYA 200 VSTFAMVKGY 210 FFPTSARDCK 220 FTGNFFYNYM 230 MGIEFNPRIG 240 KWFDFKLFFN 250 GRPGIVAWTL 260 INLSFAAKQR 270 ELHSHVTNAM 280 VLVNVLQAIY 290 VIDFFWNETW 300 YLKTIDICHD 310 HFGWYLGWGD 320 CVWLPYLYTL 330 QGLYLVYHPV 340 QLSTPHAVGV 350 LLLGLVGYYI 360 FRVANHQKDL 370 FRRTDGRCLI 380 WGRKPKVIEC 390 SYTSADGQRH 400 HSKLLVSGFW 410 GVARHFNYVG 420 DLMGSLAYCL 430 ACGGGHLLPY 440 FYIIYMAILL 450 THRCLRDEHR 460 CASKYGRDWE 470 RYTAAVPYRL LPGIF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005640	nuclear outer membrane
Molecular Function	GO:0047598	7-dehydrocholesterol reductase activity
Molecular Function	GO:0033963	cholesterol-5,6-oxide hydrolase activity
Molecular Function	GO:0050661	NADP binding
Biological Process	GO:0006695	cholesterol biosynthetic process
Biological Process	GO:0033489	cholesterol biosynthetic process via desmosterol
Biological Process	GO:0033490	cholesterol biosynthetic process via lathosterol
Biological Process	GO:0160020	positive regulation of ferroptosis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.