Search Results
Overview
| Uniprot ID | Q9UBN4 |
|---|---|
| Protein Name | Short transient receptor potential channel 4 |
| Gene Name | TRPC4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 249 | EELSRQCKQFAKDLL |
Function
Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185). Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185)
Protein Sequence
10
MAQFYYKRNV
20
NAPYRDRIPL
30
RIVRAESELS
40
PSEKAYLNAV
50
EKGDYASVKK
60
SLEEAEIYFK
70
ININCIDPLG
80
RTALLIAIEN
90
ENLELIELLL
100
SFNVYVGDAL
110
LHAIRKEVVG
120
AVELLLNHKK
130
PSGEKQVPPI
140
LLDKQFSEFT
150
PDITPIILAA
160
HTNNYEIIKL
170
LVQKGVSVPR
180
PHEVRCNCVE
190
CVSSSDVDSL
200
RHSRSRLNIY
210
KALASPSLIA
220
LSSEDPFLTA
230
FQLSWELQEL
240
SKVENEFKSE
250
YEELSRQCKQ
260
FAKDLLDQTR
270
SSRELEIILN
280
YRDDNSLIEE
290
QSGNDLARLK
300
LAIKYRQKEF
310
VAQPNCQQLL
320
ASRWYDEFPG
330
WRRRHWAVKM
340
VTCFIIGLLF
350
PVFSVCYLIA
360
PKSPLGLFIR
370
KPFIKFICHT
380
ASYLTFLFLL
390
LLASQHIDRS
400
DLNRQGPPPT
410
IVEWMILPWV
420
LGFIWGEIKQ
430
MWDGGLQDYI
440
HDWWNLMDFV
450
MNSLYLATIS
460
LKIVAFVKYS
470
ALNPRESWDM
480
WHPTLVAEAL
490
FAIANIFSSL
500
RLISLFTANS
510
HLGPLQISLG
520
RMLLDILKFL
530
FIYCLVLLAF
540
ANGLNQLYFY
550
YEETKGLTCK
560
GIRCEKQNNA
570
FSTLFETLQS
580
LFWSIFGLIN
590
LYVTNVKAQH
600
EFTEFVGATM
610
FGTYNVISLV
620
VLLNMLIAMM
630
NNSYQLIADH
640
ADIEWKFART
650
KLWMSYFEEG
660
GTLPTPFNVI
670
PSPKSLWYLI
680
KWIWTHLCKK
690
KMRRKPESFG
700
TIGRRAADNL
710
RRHHQYQEVM
720
RNLVKRYVAA
730
MIRDAKTEEG
740
LTEENFKELK
750
QDISSFRFEV
760
LGLLRGSKLS
770
TIQSANASKE
780
SSNSADSDEK
790
SDSEGNSKDK
800
KKNFSLFDLT
810
TLIHPRSAAI
820
ASERHNISNG
830
SALVVQEPPR
840
EKQRKVNFVT
850
DIKNFGLFHR
860
RSKQNAAEQN
870
ANQIFSVSEE
880
VARQQAAGPL
890
ERNIQLESRG
900
LASRGDLSIP
910
GLSEQCVLVD
920
HRERNTDTLG
930
LQVGKRVCPF
940
KSEKVVVEDT
950
VPIIPKEKHA
960
KEEDSSIDYD
970
LNLPDTVTHE
DYVTTRL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0034704 | calcium channel complex |
| Cellular Component | GO:0034703 | cation channel complex |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005262 | calcium channel activity |
| Molecular Function | GO:0070679 | inositol 1,4,5 trisphosphate binding |
| Molecular Function | GO:0005261 | monoatomic cation channel activity |
| Molecular Function | GO:0015279 | store-operated calcium channel activity |
| Biological Process | GO:0070509 | calcium ion import |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0051899 | membrane depolarization |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0003254 | regulation of membrane depolarization |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.