Search Results

Overview

Uniprot IDQ9UBQ7
Protein NameGlyoxylate reductase/hydroxypyruvate reductase
Gene NameGRHPR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
142 NGGWTSWKPLWLCGY
173 QAIARRLKPFGVQRF
235 KDFFQKMKETAVFIN
43 SDEPIPAKELERGVA
65 LLSDHVDKRILDAAG
8 MRPVRLMKVFVTRRI
94 HLALDEIKKRGIRVG

Function

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate

Protein Sequence

10 MRPVRLMKVF 20 VTRRIPAEGR 30 VALARAADCE 40 VEQWDSDEPI 50 PAKELERGVA 60 GAHGLLCLLS 70 DHVDKRILDA 80 AGANLKVIST 90 MSVGIDHLAL 100 DEIKKRGIRV 110 GYTPDVLTDT 120 TAELAVSLLL 130 TTCRRLPEAI 140 EEVKNGGWTS 150 WKPLWLCGYG 160 LTQSTVGIIG 170 LGRIGQAIAR 180 RLKPFGVQRF 190 LYTGRQPRPE 200 EAAEFQAEFV 210 STPELAAQSD 220 FIVVACSLTP 230 ATEGLCNKDF 240 FQKMKETAVF 250 INISRGDVVN 260 QDDLYQALAS 270 GKIAAAGLDV 280 TSPEPLPTNH 290 PLLTLKNCVI 300 LPHIGSATHR 310 TRNTMSLLAA 320 NNLLAGLRGE PMPSELKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005782 peroxisomal matrix
Molecular Function GO:0031406 carboxylic acid binding
Molecular Function GO:0030267 glyoxylate reductase (NADPH) activity
Molecular Function GO:0008465 hydroxypyruvate reductase (NADH) activity
Molecular Function GO:0120509 hydroxypyruvate reductase (NADPH) activity
Molecular Function GO:0016618 hydroxypyruvate reductase [NAD(P)H] activity
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0070402 NADPH binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0019752 carboxylic acid metabolic process
Biological Process GO:0043648 dicarboxylic acid metabolic process
Biological Process GO:0046487 glyoxylate metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.