Search Results

Overview

Uniprot IDQ9UBR1
Protein NameBeta-ureidopropionase
Gene NameUPB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 FAFCTREKLPWTEFA
153 PTTRFCQKLAKNHDM
304 EFTSGDGKKAHQDFG
305 FTSGDGKKAHQDFGY
32 VKRVLYGKELRKLDL
374 RELAEAVKSNYSPTI

Function

Catalyzes a late step in pyrimidine degradation (PubMed:22525402, PubMed:24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:10415095, PubMed:10542323, PubMed:11508704, PubMed:22525402, PubMed:24526388, PubMed:29976570). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable)

Protein Sequence

10 MAGAEWKSLE 20 ECLEKHLPLP 30 DLQEVKRVLY 40 GKELRKLDLP 50 REAFEAASRE 60 DFELQGYAFE 70 AAEEQLRRPR 80 IVHVGLVQNR 90 IPLPANAPVA 100 EQVSALHRRI 110 KAIVEVAAMC 120 GVNIICFQEA 130 WTMPFAFCTR 140 EKLPWTEFAE 150 SAEDGPTTRF 160 CQKLAKNHDM 170 VVVSPILERD 180 SEHGDVLWNT 190 AVVISNSGAV 200 LGKTRKNHIP 210 RVGDFNESTY 220 YMEGNLGHPV 230 FQTQFGRIAV 240 NICYGRHHPL 250 NWLMYSINGA 260 EIIFNPSATI 270 GALSESLWPI 280 EARNAAIANH 290 CFTCAINRVG 300 TEHFPNEFTS 310 GDGKKAHQDF 320 GYFYGSSYVA 330 APDSSRTPGL 340 SRSRDGLLVA 350 KLDLNLCQQV 360 NDVWNFKMTG 370 RYEMYARELA 380 EAVKSNYSPT IVKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0003837 beta-ureidopropionase activity
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0033396 beta-alanine biosynthetic process via 3-ureidopropionate
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0001889 liver development
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0046135 pyrimidine nucleoside catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.