Search Results
Overview
| Uniprot ID | Q9UBR2 |
|---|---|
| Protein Name | Cathepsin Z |
| Gene Name | CTSZ |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 281 | RIVTSTYKDGKGARY |
Function
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity)
Protein Sequence
10
MARRGPGWRP
20
LLLLVLLAGA
30
AQGGLYFRRG
40
QTCYRPLRGD
50
GLAPLGRSTY
60
PRPHEYLSPA
70
DLPKSWDWRN
80
VDGVNYASIT
90
RNQHIPQYCG
100
SCWAHASTSA
110
MADRINIKRK
120
GAWPSTLLSV
130
QNVIDCGNAG
140
SCEGGNDLSV
150
WDYAHQHGIP
160
DETCNNYQAK
170
DQECDKFNQC
180
GTCNEFKECH
190
AIRNYTLWRV
200
GDYGSLSGRE
210
KMMAEIYANG
220
PISCGIMATE
230
RLANYTGGIY
240
AEYQDTTYIN
250
HVVSVAGWGI
260
SDGTEYWIVR
270
NSWGEPWGER
280
GWLRIVTSTY
290
KDGKGARYNL
300
AIEEHCTFGD
PIV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0030134 | COPII-coated ER to Golgi transport vesicle |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0035580 | specific granule lumen |
| Molecular Function | GO:0004180 | carboxypeptidase activity |
| Molecular Function | GO:0016807 | cysteine-type carboxypeptidase activity |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0008234 | cysteine-type peptidase activity |
| Biological Process | GO:0002003 | angiotensin maturation |
| Biological Process | GO:0060441 | epithelial tube branching involved in lung morphogenesis |
| Biological Process | GO:0010757 | negative regulation of plasminogen activation |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0051603 | proteolysis involved in protein catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.