Overview
| Uniprot ID | Q9UBS4 |
|---|
| Protein Name | DnaJ homolog subfamily B member 11 |
|---|
| Gene Name | DNAJB11 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 247 |
RFRIKVVKHPIFERR |
| 84 |
LSDSEKRKQYDTYGE |
Function
As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351)
Protein Sequence
10
MAPQNLSTFC
20
LLLLYLIGAV
30
IAGRDFYKIL
40
GVPRSASIKD
50
IKKAYRKLAL
60
QLHPDRNPDD
70
PQAQEKFQDL
80
GAAYEVLSDS
90
EKRKQYDTYG
100
EEGLKDGHQS
110
SHGDIFSHFF
120
GDFGFMFGGT
130
PRQQDRNIPR
140
GSDIIVDLEV
150
TLEEVYAGNF
160
VEVVRNKPVA
170
RQAPGKRKCN
180
CRQEMRTTQL
190
GPGRFQMTQE
200
VVCDECPNVK
210
LVNEERTLEV
220
EIEPGVRDGM
230
EYPFIGEGEP
240
HVDGEPGDLR
250
FRIKVVKHPI
260
FERRGDDLYT
270
NVTISLVESL
280
VGFEMDITHL
290
DGHKVHISRD
300
KITRPGAKLW
310
KKGEGLPNFD
320
NNNIKGSLII
330
TFDVDFPKEQ
340
LTEEAREGIK
350
QLLKQGSVQK
VYNGLQGY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0034663 |
endoplasmic reticulum chaperone complex |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0101031 |
protein folding chaperone complex |
| Molecular Function |
GO:0051787 |
misfolded protein binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Molecular Function |
GO:0051082 |
unfolded protein binding |
| Biological Process |
GO:0032781 |
positive regulation of ATP-dependent activity |
| Biological Process |
GO:0006457 |
protein folding |
| Biological Process |
GO:0051604 |
protein maturation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.