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Overview

Uniprot IDQ9UBT2
Protein NameSUMO-activating enzyme subunit 2
Gene NameUBA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
420 CRTIFLNKQPNPRKK
613 EERSRKRKLDEKENL
623 EKENLSAKRSRIEQK

Function

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2

Protein Sequence

10 MALSRGLPRE 20 LAEAVAGGRV 30 LVVGAGGIGC 40 ELLKNLVLTG 50 FSHIDLIDLD 60 TIDVSNLNRQ 70 FLFQKKHVGR 80 SKAQVAKESV 90 LQFYPKANIV 100 AYHDSIMNPD 110 YNVEFFRQFI 120 LVMNALDNRA 130 ARNHVNRMCL 140 AADVPLIESG 150 TAGYLGQVTT 160 IKKGVTECYE 170 CHPKPTQRTF 180 PGCTIRNTPS 190 EPIHCIVWAK 200 YLFNQLFGEE 210 DADQEVSPDR 220 ADPEAAWEPT 230 EAEARARASN 240 EDGDIKRIST 250 KEWAKSTGYD 260 PVKLFTKLFK 270 DDIRYLLTMD 280 KLWRKRKPPV 290 PLDWAEVQSQ 300 GEETNASDQQ 310 NEPQLGLKDQ 320 QVLDVKSYAR 330 LFSKSIETLR 340 VHLAEKGDGA 350 ELIWDKDDPS 360 AMDFVTSAAN 370 LRMHIFSMNM 380 KSRFDIKSMA 390 GNIIPAIATT 400 NAVIAGLIVL 410 EGLKILSGKI 420 DQCRTIFLNK 430 QPNPRKKLLV 440 PCALDPPNPN 450 CYVCASKPEV 460 TVRLNVHKVT 470 VLTLQDKIVK 480 EKFAMVAPDV 490 QIEDGKGTIL 500 ISSEEGETEA 510 NNHKKLSEFG 520 IRNGSRLQAD 530 DFLQDYTLLI 540 NILHSEDLGK 550 DVEFEVVGDA 560 PEKVGPKQAE 570 DAAKSITNGS 580 DDGAQPSTST 590 AQEQDDVLIV 600 DSDEEDSSNN 610 ADVSEEERSR 620 KRKLDEKENL 630 SAKRSRIEQK 640 EELDDVIALD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0016925 protein sumoylation
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0031510 SUMO activating enzyme complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0044388 small protein activating enzyme binding
Molecular Function GO:0019948 SUMO activating enzyme activity
Molecular Function GO:0032183 SUMO binding
Molecular Function GO:0016740 transferase activity
Molecular Function GO:0044390 ubiquitin-like protein conjugating enzyme binding
Biological Process GO:0033235 positive regulation of protein sumoylation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.