Search Results

Overview

Uniprot ID	Q9UBU9
Protein Name	Nuclear RNA export factor 1
Gene Name	NXF1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
32	GRGPFRWKYGEGNRR

Function

Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244)

Protein Sequence

10 MADEGKSYSE 20 HDDERVNFPQ 30 RKKKGRGPFR 40 WKYGEGNRRS 50 GRGGSGIRSS 60 RLEEDDGDVA 70 MSDAQDGPRV 80 RYNPYTTRPN 90 RRGDTWHDRD 100 RIHVTVRRDR 110 APPERGGAGT 120 SQDGTSKNWF 130 KITIPYGRKY 140 DKAWLLSMIQ 150 SKCSVPFTPI 160 EFHYENTRAQ 170 FFVEDASTAS 180 ALKAVNYKIL 190 DRENRRISII 200 INSSAPPHTI 210 LNELKPEQVE 220 QLKLIMSKRY 230 DGSQQALDLK 240 GLRSDPDLVA 250 QNIDVVLNRR 260 SCMAATLRII 270 EENIPELLSL 280 NLSNNRLYRL 290 DDMSSIVQKA 300 PNLKILNLSG 310 NELKSERELD 320 KIKGLKLEEL 330 WLDGNSLCDT 340 FRDQSTYISA 350 IRERFPKLLR 360 LDGHELPPPI 370 AFDVEAPTTL 380 PPCKGSYFGT 390 ENLKSLVLHF 400 LQQYYAIYDS 410 GDRQGLLDAY 420 HDGACCSLSI 430 PFIPQNPARS 440 SLAEYFKDSR 450 NVKKLKDPTL 460 RFRLLKHTRL 470 NVVAFLNELP 480 KTQHDVNSFV 490 VDISAQTSTL 500 LCFSVNGVFK 510 EVDGKSRDSL 520 RAFTRTFIAV 530 PASNSGLCIV 540 NDELFVRNAS 550 SEEIQRAFAM 560 PAPTPSSSPV 570 PTLSPEQQEM 580 LQAFSTQSGM 590 NLEWSQKCLQ 600 DNNWDYTRSA 610 QAFTHLKAKG EIPEVAFMK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0010494	cytoplasmic stress granule
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0042405	nuclear inclusion body
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0042272	nuclear RNA export factor complex
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006406	mRNA export from nucleus
Biological Process	GO:0016973	poly(A)+ mRNA export from nucleus
Biological Process	GO:0015031	protein transport

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.