Search Results

Overview

Uniprot IDQ9UBV2
Protein NameProtein sel-1 homolog 1
Gene NameSEL1L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
688 KQDIHLAKRFYDMAA

Function

Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207, PubMed:37943610, PubMed:37943617). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling

Protein Sequence

10 MRVRIGLTLL 20 LCAVLLSLAS 30 ASSDEEGSQD 40 ESLDSKTTLT 50 SDESVKDHTT 60 AGRVVAGQIF 70 LDSEESELES 80 SIQEEEDSLK 90 SQEGESVTED 100 ISFLESPNPE 110 NKDYEEPKKV 120 RKPALTAIEG 130 TAHGEPCHFP 140 FLFLDKEYDE 150 CTSDGREDGR 160 LWCATTYDYK 170 ADEKWGFCET 180 EEEAAKRRQM 190 QEAEMMYQTG 200 MKILNGSNKK 210 SQKREAYRYL 220 QKAASMNHTK 230 ALERVSYALL 240 FGDYLPQNIQ 250 AAREMFEKLT 260 EEGSPKGQTA 270 LGFLYASGLG 280 VNSSQAKALV 290 YYTFGALGGN 300 LIAHMVLGYR 310 YWAGIGVLQS 320 CESALTHYRL 330 VANHVASDIS 340 LTGGSVVQRI 350 RLPDEVENPG 360 MNSGMLEEDL 370 IQYYQFLAEK 380 GDVQAQVGLG 390 QLHLHGGRGV 400 EQNHQRAFDY 410 FNLAANAGNS 420 HAMAFLGKMY 430 SEGSDIVPQS 440 NETALHYFKK 450 AADMGNPVGQ 460 SGLGMAYLYG 470 RGVQVNYDLA 480 LKYFQKAAEQ 490 GWVDGQLQLG 500 SMYYNGIGVK 510 RDYKQALKYF 520 NLASQGGHIL 530 AFYNLAQMHA 540 SGTGVMRSCH 550 TAVELFKNVC 560 ERGRWSERLM 570 TAYNSYKDGD 580 YNAAVIQYLL 590 LAEQGYEVAQ 600 SNAAFILDQR 610 EASIVGENET 620 YPRALLHWNR 630 AASQGYTVAR 640 IKLGDYHFYG 650 FGTDVDYETA 660 FIHYRLASEQ 670 QHSAQAMFNL 680 GYMHEKGLGI 690 KQDIHLAKRF 700 YDMAAEASPD 710 AQVPVFLALC 720 KLGVVYFLQY 730 IRETNIRDMF 740 TQLDMDQLLG 750 PEWDLYLMTI 760 IALLLGTVIA 770 YRQRQHQDMP 780 APRPPGPRPA 790 PPQQEGPPEQ QPPQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0036513 Derlin-1 retrotranslocation complex
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0000836 Hrd1p ubiquitin ligase complex
Cellular Component GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0009306 protein secretion
Biological Process GO:0050821 protein stabilization
Biological Process GO:0030970 retrograde protein transport, ER to cytosol
Biological Process GO:0006641 triglyceride metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.