Search Results
Overview
| Uniprot ID | Q9UBW5 |
|---|---|
| Protein Name | Bridging integrator 2 |
| Gene Name | BIN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MAEGKAGGAAGL |
Function
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis
Protein Sequence
10
MAEGKAGGAA
20
GLFAKQVQKK
30
FSRAQEKVLQ
40
KLGKAVETKD
50
ERFEQSASNF
60
YQQQAEGHKL
70
YKDLKNFLSA
80
VKVMHESSKR
90
VSETLQEIYS
100
SEWDGHEELK
110
AIVWNNDLLW
120
EDYEEKLADQ
130
AVRTMEIYVA
140
QFSEIKERIA
150
KRGRKLVDYD
160
SARHHLEAVQ
170
NAKKKDEAKT
180
AKAEEEFNKA
190
QTVFEDLNQE
200
LLEELPILYN
210
SRIGCYVTIF
220
QNISNLRDVF
230
YREMSKLNHN
240
LYEVMSKLEK
250
QHSNKVFVVK
260
GLSSSSRRSL
270
VISPPVRTAT
280
VSSPLTSPTS
290
PSTLSLKSES
300
ESVSATEDLA
310
PDAAQGEDNS
320
EIKELLEEEE
330
IEKEGSEASS
340
SEEDEPLPAC
350
NGPAQAQPSP
360
TTERAKSQEE
370
VLPSSTTPSP
380
GGALSPSGQP
390
SSSATEVVLR
400
TRTASEGSEQ
410
PKKRASIQRT
420
SAPPSRPPPP
430
RATASPRPSS
440
GNIPSSPTAS
450
GGGSPTSPRA
460
SLGTGTASPR
470
TSLEVSPNPE
480
PPEKPVRTPE
490
AKENENIHNQ
500
NPEELCTSPT
510
LMTSQVASEP
520
GEAKKMEDKE
530
KDNKLISANS
540
SEGQDQLQVS
550
MVPENNNLTA
560
PEPQEEVSTS
ENPQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0001891 | phagocytic cup |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0005543 | phospholipid binding |
| Biological Process | GO:0060326 | cell chemotaxis |
| Biological Process | GO:0006911 | phagocytosis, engulfment |
| Biological Process | GO:0097320 | plasma membrane tubulation |
| Biological Process | GO:0071800 | podosome assembly |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.