Search Results

Overview

Uniprot IDQ9UBW7
Protein NameZinc finger MYM-type protein 2
Gene NameZMYM2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
104 SKITPSSKELASQKG
1099 LLVLDELKSSKSVKL
1102 LDELKSSKSVKLKED
1280 EDKITTGKRKHEDDE
297 ASFPRNQKQPGVDSL
325 SVQQQPTKPVKVTCA
328 QQPTKPVKVTCANCK
340 NCKKPLQKGQTAYQR
417 EDKQNPTKGALNKSR
441 IRHEVSFKNMTHKLC
446 SFKNMTHKLCSDHCF
503 QSCVSEYKQVGSHPS
513 GSHPSFLKEVRDHMQ
529 SFLMQPEKYGKLTTC
532 MQPEKYGKLTTCTGC
576 SHKTKYAKSQSLGII
812 EPNMTTQKGPENLHY
829 GCQTSRTKMTGSAPP
88 TITFTSSKNEELQGN
98 ELQGNDSKITPSSKE

Function

Involved in the negative regulation of transcription

Protein Sequence

10 MDTSSVGGLE 20 LTDQTPVLLG 30 STAMATSLTN 40 VGNSFSGPAN 50 PLVSRSNKFQ 60 NSSVEDDDDV 70 VFIEPVQPPP 80 PSVPVVADQR 90 TITFTSSKNE 100 ELQGNDSKIT 110 PSSKELASQK 120 GSVSETIVID 130 DEEDMETNQG 140 QEKNSSNFIE 150 RRPPETKNRT 160 NDVDFSTSSF 170 SRSKVNAGMG 180 NSGITTEPDS 190 EIQIANVTTL 200 ETGVSSVNDG 210 QLENTDGRDM 220 NLMITHVTSL 230 QNTNLGDVSN 240 GLQSSNFGVN 250 IQTYTPSLTS 260 QTKTGVGPFN 270 PGRMNVAGDV 280 FQNGESATHH 290 NPDSWISQSA 300 SFPRNQKQPG 310 VDSLSPVASL 320 PKQIFQPSVQ 330 QQPTKPVKVT 340 CANCKKPLQK 350 GQTAYQRKGS 360 AHLFCSTTCL 370 SSFSHKPAPK 380 KLCVMCKKDI 390 TTMKGTIVAQ 400 VDSSESFQEF 410 CSTSCLSLYE 420 DKQNPTKGAL 430 NKSRCTICGK 440 LTEIRHEVSF 450 KNMTHKLCSD 460 HCFNRYRMAN 470 GLIMNCCEQC 480 GEYLPSKGAG 490 NNVLVIDGQQ 500 KRFCCQSCVS 510 EYKQVGSHPS 520 FLKEVRDHMQ 530 DSFLMQPEKY 540 GKLTTCTGCR 550 TQCRFFDMTQ 560 CIGPNGYMEP 570 YCSTACMNSH 580 KTKYAKSQSL 590 GIICHFCKRN 600 SLPQYQATMP 610 DGKLYNFCNS 620 SCVAKFQALS 630 MQSSPNGQFV 640 APSDIQLKCN 650 YCKNSFCSKP 660 EILEWENKVH 670 QFCSKTCSDD 680 YKKLHCIVTY 690 CEYCQEEKTL 700 HETVNFSGVK 710 RPFCSEGCKL 720 LYKQDFARRL 730 GLRCVTCNYC 740 SQLCKKGATK 750 ELDGVVRDFC 760 SEDCCKKFQD 770 WYYKAARCDC 780 CKSQGTLKER 790 VQWRGEMKHF 800 CDQHCLLRFY 810 CQQNEPNMTT 820 QKGPENLHYD 830 QGCQTSRTKM 840 TGSAPPPSPT 850 PNKEMKNKAV 860 LCKPLTMTKA 870 TYCKPHMQTK 880 SCQTDDTWRT 890 EYVPVPIPVP 900 VYIPVPMHMY 910 SQNIPVPTTV 920 PVPVPVPVFL 930 PAPLDSSEKI 940 PAAIEELKSK 950 VSSDALDTEL 960 LTMTDMMSED 970 EGKTETTNIN 980 SVIIETDIIG 990 SDLLKNSDPE 1000 TQSSMPDVPY 1010 EPDLDIEIDF 1020 PRAAEELDME 1030 NEFLLPPVFG 1040 EEYEEQPRPR 1050 SKKKGAKRKA 1060 VSGYQSHDDS 1070 SDNSECSFPF 1080 KYTYGVNAWK 1090 HWVKTRQLDE 1100 DLLVLDELKS 1110 SKSVKLKEDL 1120 LSHTTAELNY 1130 GLAHFVNEIR 1140 RPNGENYAPD 1150 SIYYLCLGIQ 1160 EYLCGSNRKD 1170 NIFIDPGYQT 1180 FEQELNKILR 1190 SWQPSILPDG 1200 SIFSRVEEDY 1210 LWRIKQLGSH 1220 SPVALLNTLF 1230 YFNTKYFGLK 1240 TVEQHLRLSF 1250 GTVFRHWKKN 1260 PLTMENKACL 1270 RYQVSSLCGT 1280 DNEDKITTGK 1290 RKHEDDEPVF 1300 EQIENTANPS 1310 RCPVKMFECY 1320 LSKSPQNLNQ 1330 RMDVFYLQPE 1340 CSSSTDSPVW 1350 YTSTSLDRNT 1360 LENMLVRVLL 1370 VKDIYDKDNY ELDEDTD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016605 PML body
Molecular Function GO:0031624 ubiquitin conjugating enzyme binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.