Overview
| Uniprot ID | Q9UBX3 |
|---|
| Protein Name | Mitochondrial dicarboxylate carrier |
|---|
| Gene Name | SLC25A10 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 132 |
VRMQNDVKLPQGQRR |
| 231 |
KTRLMNSKGEYQGVF |
| 41 |
LQTQQEVKLRMTGMA |
| 91 |
TVRDRVAKGSQGPLP |
Function
Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across the mitochondrial inner membrane (PubMed:29211846, PubMed:38780415, PubMed:38937634). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed:38937634). Does not transport glutathione (By similarity). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity)
Protein Sequence
10
MAAEARVSRW
20
YFGGLASCGA
30
ACCTHPLDLL
40
KVHLQTQQEV
50
KLRMTGMALR
60
VVRTDGILAL
70
YSGLSASLCR
80
QMTYSLTRFA
90
IYETVRDRVA
100
KGSQGPLPFH
110
EKVLLGSVSG
120
LAGGFVGTPA
130
DLVNVRMQND
140
VKLPQGQRRN
150
YAHALDGLYR
160
VAREEGLRRL
170
FSGATMASSR
180
GALVTVGQLS
190
CYDQAKQLVL
200
STGYLSDNIF
210
THFVASFIAG
220
GCATFLCQPL
230
DVLKTRLMNS
240
KGEYQGVFHC
250
AVETAKLGPL
260
AFYKGLVPAG
270
IRLIPHTVLT
280
FVFLEQLRKN
FGIKVPS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0015297 |
antiporter activity |
| Molecular Function |
GO:0005310 |
dicarboxylic acid transmembrane transporter activity |
| Molecular Function |
GO:0015140 |
malate transmembrane transporter activity |
| Molecular Function |
GO:0015131 |
oxaloacetate transmembrane transporter activity |
| Molecular Function |
GO:0015141 |
succinate transmembrane transporter activity |
| Molecular Function |
GO:0015116 |
sulfate transmembrane transporter activity |
| Molecular Function |
GO:0015117 |
thiosulfate transmembrane transporter activity |
| Biological Process |
GO:0006835 |
dicarboxylic acid transport |
| Biological Process |
GO:0006094 |
gluconeogenesis |
| Biological Process |
GO:0046166 |
glyceraldehyde-3-phosphate biosynthetic process |
| Biological Process |
GO:0006869 |
lipid transport |
| Biological Process |
GO:0071423 |
malate transmembrane transport |
| Biological Process |
GO:0015711 |
organic anion transport |
| Biological Process |
GO:0015729 |
oxaloacetate transport |
| Biological Process |
GO:0035435 |
phosphate ion transmembrane transport |
| Biological Process |
GO:0071422 |
succinate transmembrane transport |
| Biological Process |
GO:1902358 |
sulfate transmembrane transport |
| Biological Process |
GO:0070221 |
sulfide oxidation, using sulfide:quinone oxidoreductase |
| Biological Process |
GO:0015709 |
thiosulfate transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.