Search Results

Overview

Uniprot IDQ9UDR5
Protein NameAlpha-aminoadipic semialdehyde synthase, mitochondrial
Gene NameAASS
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
104 EEKLMSRKTYAFFSH
259 SQTGDLRKVYGTVLS
274 RHHHLVRKTDAVYDP
286 YDPAEYDKHPERYIS
458 SNGTLPDKYKYIQTL
460 GTLPDKYKYIQTLRE
48 PLAPKHIKGITNLGY
522 NQIEQLGKKYNINPV
535 PVSMDICKQEEKLGF
539 DICKQEEKLGFLVAK

Function

Bifunctional enzyme that catalyzes the first two steps in lysine degradation

Protein Sequence

10 MLQVHRTGLG 20 RLGVSLSKGL 30 HHKAVLAVRR 40 EDVNAWERRA 50 PLAPKHIKGI 60 TNLGYKVLIQ 70 PSNRRAIHDK 80 DYVKAGGILQ 90 EDISEACLIL 100 GVKRPPEEKL 110 MSRKTYAFFS 120 HTIKAQEANM 130 GLLDEILKQE 140 IRLIDYEKMV 150 DHRGVRVVAF 160 GQWAGVAGMI 170 NILHGMGLRL 180 LALGHHTPFM 190 HIGMAHNYRN 200 SSQAVQAVRD 210 AGYEISLGLM 220 PKSIGPLTFV 230 FTGTGNVSKG 240 AQAIFNELPC 250 EYVEPHELKE 260 VSQTGDLRKV 270 YGTVLSRHHH 280 LVRKTDAVYD 290 PAEYDKHPER 300 YISRFNTDIA 310 PYTTCLINGI 320 YWEQNTPRLL 330 TRQDAQSLLA 340 PGKFSPAGVE 350 GCPALPHKLV 360 AICDISADTG 370 GSIEFMTECT 380 TIEHPFCMYD 390 ADQHIIHDSV 400 EGSGILMCSI 410 DNLPAQLPIE 420 ATECFGDMLY 430 PYVEEMILSD 440 ATQPLESQNF 450 SPVVRDAVIT 460 SNGTLPDKYK 470 YIQTLRESRE 480 RAQSLSMGTR 490 RKVLVLGSGY 500 ISEPVLEYLS 510 RDGNIEITVG 520 SDMKNQIEQL 530 GKKYNINPVS 540 MDICKQEEKL 550 GFLVAKQDLV 560 ISLLPYVLHP 570 LVAKACITNK 580 VNMVTASYIT 590 PALKELEKSV 600 EDAGITIIGE 610 LGLDPGLDHM 620 LAMETIDKAK 630 EVGATIESYI 640 SYCGGLPAPE 650 HSNNPLRYKF 660 SWSPVGVLMN 670 VMQSATYLLD 680 GKVVNVAGGI 690 SFLDAVTSMD 700 FFPGLNLEGY 710 PNRDSTKYAE 720 IYGISSAHTL 730 LRGTLRYKGY 740 MKALNGFVKL 750 GLINREALPA 760 FRPEANPLTW 770 KQLLCDLVGI 780 SPSSEHDVLK 790 EAVLKKLGGD 800 NTQLEAAEWL 810 GLLGDEQVPQ 820 AESILDALSK 830 HLVMKLSYGP 840 EEKDMIVMRD 850 SFGIRHPSGH 860 LEHKTIDLVA 870 YGDINGFSAM 880 AKTVGLPTAM 890 AAKMLLDGEI 900 GAKGLMGPFS 910 KEIYGPILER 920 IKAEGIIYTT QSTIKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042393 histone binding
Molecular Function GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity
Molecular Function GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
Molecular Function GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
Molecular Function GO:0004753 saccharopine dehydrogenase activity
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0019878 L-lysine biosynthetic process via aminoadipic acid
Biological Process GO:0033512 L-lysine catabolic process to acetyl-CoA via L-saccharopine
Biological Process GO:0006554 lysine catabolic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.