Search Results

Overview

Uniprot IDQ9UDY2
Protein NameTight junction protein 2
Gene NameTJP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1003 PKAKTQNKEESYDFS
769 PKDAGSEKSTGVVRL

Function

Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity)

Protein Sequence

10 MPVRGDRGFP 20 PRRELSGWLR 30 APGMEELIWE 40 QYTVTLQKDS 50 KRGFGIAVSG 60 GRDNPHFENG 70 ETSIVISDVL 80 PGGPADGLLQ 90 ENDRVVMVNG 100 TPMEDVLHSF 110 AVQQLRKSGK 120 VAAIVVKRPR 130 KVQVAALQAS 140 PPLDQDDRAF 150 EVMDEFDGRS 160 FRSGYSERSR 170 LNSHGGRSRS 180 WEDSPERGRP 190 HERARSRERD 200 LSRDRSRGRS 210 LERGLDQDHA 220 RTRDRSRGRS 230 LERGLDHDFG 240 PSRDRDRDRS 250 RGRSIDQDYE 260 RAYHRAYDPD 270 YERAYSPEYR 280 RGARHDARSR 290 GPRSRSREHP 300 HSRSPSPEPR 310 GRPGPIGVLL 320 MKSRANEEYG 330 LRLGSQIFVK 340 EMTRTGLATK 350 DGNLHEGDII 360 LKINGTVTEN 370 MSLTDARKLI 380 EKSRGKLQLV 390 VLRDSQQTLI 400 NIPSLNDSDS 410 EIEDISEIES 420 NRSFSPEERR 430 HQYSDYDYHS 440 SSEKLKERPS 450 SREDTPSRLS 460 RMGATPTPFK 470 STGDIAGTVV 480 PETNKEPRYQ 490 EDPPAPQPKA 500 APRTFLRPSP 510 EDEAIYGPNT 520 KMVRFKKGDS 530 VGLRLAGGND 540 VGIFVAGIQE 550 GTSAEQEGLQ 560 EGDQILKVNT 570 QDFRGLVRED 580 AVLYLLEIPK 590 GEMVTILAQS 600 RADVYRDILA 610 CGRGDSFFIR 620 SHFECEKETP 630 QSLAFTRGEV 640 FRVVDTLYDG 650 KLGNWLAVRI 660 GNELEKGLIP 670 NKSRAEQMAS 680 VQNAQRDNAG 690 DRADFWRMRG 700 QRSGVKKNLR 710 KSREDLTAVV 720 SVSTKFPAYE 730 RVLLREAGFK 740 RPVVLFGPIA 750 DIAMEKLANE 760 LPDWFQTAKT 770 EPKDAGSEKS 780 TGVVRLNTVR 790 QIIEQDKHAL 800 LDVTPKAVDL 810 LNYTQWFPIV 820 IFFNPDSRQG 830 VKTMRQRLNP 840 TSNKSSRKLF 850 DQANKLKKTC 860 AHLFTATINL 870 NSANDSWFGS 880 LKDTIQHQQG 890 EAVWVSEGKM 900 EGMDDDPEDR 910 MSYLTAMGAD 920 YLSCDSRLIS 930 DFEDTDGEGG 940 AYTDNELDEP 950 AEEPLVSSIT 960 RSSEPVQHEE 970 SIRKPSPEPR 980 AQMRRAASSD 990 QLRDNSPPPA 1000 FKPEPPKAKT 1010 QNKEESYDFS 1020 KSYEYKSNPS 1030 AVAGNETPGA 1040 STKGYPPPVA 1050 AKPTFGRSIL 1060 KPSTPIPPQE 1070 GEEVGESSEE 1080 QDNAPKSVLG 1090 KVKIFEKMDH 1100 KARLQRMQEL 1110 QEAQNARIEI 1120 AQKHPDIYAV 1130 PIKTHKPDPG 1140 TPQHTSSRPP 1150 EPQKAPSRPY 1160 QDTRGSYGSD 1170 AEEEEYRQQL 1180 SEHSKRGYYG 1190 QSARYRDTEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0030054 cell junction
Cellular Component GO:0044291 cell-cell contact zone
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0050839 cell adhesion molecule binding
Molecular Function GO:0004385 GMP kinase activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:1990782 protein tyrosine kinase binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0090557 establishment of endothelial intestinal barrier
Biological Process GO:0034109 homotypic cell-cell adhesion
Biological Process GO:0050892 intestinal absorption
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:1905605 positive regulation of blood-brain barrier permeability
Biological Process GO:0150105 protein localization to cell-cell junction
Biological Process GO:0090559 regulation of membrane permeability

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.