Search Results

Overview

Uniprot IDQ9UEE9
Protein NameHeterochromatin-stabilizing protein CFDP1
Gene NameCFDP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
126 NDVGPKSKVPPSTQV
135 PPSTQVKKGEETEET
146 TEETSSSKLLVKAEE
150 SSSKLLVKAEELEKP
167 TEKVKITKVFDFAGE
180 GEEVRVTKEVDATSK
187 KEVDATSKEAKSFFK
190 DATSKEAKSFFKQNE
194 KEAKSFFKQNEKEKP
230 GMSSLLGKIGAKKQK
237 KIGAKKQKMSTLEKS
245 MSTLEKSKLDWESFK
268 LAIHNRGKEGYIERK
54 KTQGKKRKAQSIPAR

Function

Required for the structural stability of pericentromeric heterochromatin (PubMed:28367969). Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin (By similarity). Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats (By similarity). Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis (By similarity). Plays a role in craniofacial development (By similarity). Required to maintain normal cell function in embryonic development (By similarity)

Protein Sequence

10 MEEFDSEDFS 20 TSEEDEDYVP 30 SGGEYSEDDV 40 NELVKEDEVD 50 GEEQTQKTQG 60 KKRKAQSIPA 70 RKRRQGGLSL 80 EEEEEEDANS 90 ESEGSSSEEE 100 DDAAEQEKGI 110 GSEDARKKKE 120 DELWASFLND 130 VGPKSKVPPS 140 TQVKKGEETE 150 ETSSSKLLVK 160 AEELEKPKET 170 EKVKITKVFD 180 FAGEEVRVTK 190 EVDATSKEAK 200 SFFKQNEKEK 210 PQANVPSALP 220 SLPAGSGLKR 230 SSGMSSLLGK 240 IGAKKQKMST 250 LEKSKLDWES 260 FKEEEGIGEE 270 LAIHNRGKEG 280 YIERKAFLDR 290 VDHRQFEIER DLRLSKMKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0000812 Swr1 complex
Biological Process GO:0006338 chromatin remodeling

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.