Overview
| Uniprot ID | Q9UEY8 |
|---|
| Protein Name | Gamma-adducin |
|---|
| Gene Name | ADD3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 167 |
YISVRISKEQDHIII |
| 476 |
MKAEDSSKVSGGTPI |
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity)
Protein Sequence
10
MSSDASQGVI
20
TTPPPPSMPH
30
KERYFDRINE
40
NDPEYIRERN
50
MSPDLRQDFN
60
MMEQRKRVTQ
70
ILQSPAFRED
80
LECLIQEQMK
90
KGHNPTGLLA
100
LQQIADYIMA
110
NSFSGFSSPP
120
LSLGMVTPIN
130
DLPGADTSSY
140
VKGEKLTRCK
150
LASLYRLVDL
160
FGWAHLANTY
170
ISVRISKEQD
180
HIIIIPRGLS
190
FSEATASNLV
200
KVNIIGEVVD
210
QGSTNLKIDH
220
TGFSPHAAIY
230
STRPDVKCVI
240
HIHTLATAAV
250
SSMKCGILPI
260
SQESLLLGDV
270
AYYDYQGSLE
280
EQEERIQLQK
290
VLGPSCKVLV
300
LRNHGVVALG
310
ETLEEAFHYI
320
FNVQLACEIQ
330
VQALAGAGGV
340
DNLHVLDFQK
350
YKAFTYTVAA
360
SGGGGVNMGS
370
HQKWKVGEIE
380
FEGLMRTLDN
390
LGYRTGYAYR
400
HPLIREKPRH
410
KSDVEIPATV
420
TAFSFEDDTV
430
PLSPLKYMAQ
440
RQQREKTRWL
450
NSPNTYMKVN
460
VPEESRNGET
470
SPRTKITWMK
480
AEDSSKVSGG
490
TPIKIEDPNQ
500
FVPLNTNPNE
510
VLEKRNKIRE
520
QNRYDLKTAG
530
PQSQLLAGIV
540
VDKPPSTMQF
550
EDDDHGPPAP
560
PNPFSHLTEG
570
ELEEYKRTIE
580
RKQQGLEDAE
590
QELLSDDASS
600
VSQIQSQTQS
610
PQNVPEKLEE
620
NHELFSKSFI
630
SMEVPVMVVN
640
GKDDMHDVED
650
ELAKRVSRLS
660
TSTTIENIEI
670
TIKSPEKIEE
680
VLSPEGSPSK
690
SPSKKKKKFR
700
TPSFLKKNKK
KEKVEA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005903 |
brush border |
| Cellular Component |
GO:0005938 |
cell cortex |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0000794 |
condensed nuclear chromosome |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0014731 |
spectrin-associated cytoskeleton |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0005080 |
protein kinase C binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
| Biological Process |
GO:0051495 |
positive regulation of cytoskeleton organization |
| Biological Process |
GO:0045907 |
positive regulation of vasoconstriction |
| Biological Process |
GO:0030833 |
regulation of actin filament polymerization |
| Biological Process |
GO:0009410 |
response to xenobiotic stimulus |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.