Search Results

Overview

Uniprot IDQ9UFC0
Protein NameLeucine-rich repeat and WD repeat-containing protein 1
Gene NameLRWD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
233 RARLAALKRPDDVPL
246 PLSLSPSKRACASPS

Function

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability

Protein Sequence

10 MGPLSARLLM 20 QRGRPKSDRL 30 GKIRSLDLSG 40 LELLSEHLDP 50 KLLCRLTQLQ 60 ELDLSNNHLE 70 TLPDNLGLSH 80 LRVLRCANNQ 90 LGDVTALCQF 100 PKLEELSLEG 110 NPFLTVNDNL 120 KVSFLLPTLR 130 KVNGKDASST 140 YSQVENLNRE 150 LTSRVTAHWE 160 KFMATLGPEE 170 EAEKAQADFV 180 KSAVRDVRYG 190 PESLSEFTQW 200 RVRMISEELV 210 AASRTQVQKA 220 NSPEKPPEAG 230 AAHKPRARLA 240 ALKRPDDVPL 250 SLSPSKRACA 260 SPSAQVEGSP 270 VAGSDGSQPA 280 VKLEPLHFLQ 290 CHSKNNSPQD 300 LETQLWACAF 310 EPAWEEGATS 320 QTVATCGGEA 330 VCVIDCQTGI 340 VLHKYKAPGE 350 EFFSVAWTAL 360 MVVTQAGHKK 370 RWSVLAAAGL 380 RGLVRLLHVR 390 AGFCCGVIRA 400 HKKAIATLCF 410 SPAHETHLFT 420 ASYDKRIILW 430 DIGVPNQDYE 440 FQASQLLTLD 450 TTSIPLRLCP 460 VASCPDARLL 470 AGCEGGCCCW 480 DVRLDQPQKR 490 RVCEVEFVFS 500 EGSEASGRRV 510 DGLAFVNEDI 520 VASKGSGLGT 530 ICLWSWRQTW 540 GGRGSQSTVA 550 VVVLARLQWS 560 STELAYFSLS 570 ACPDKGIVLC 580 GDEEGNVWLY 590 DVSNILKQPP 600 LLPAALQAPT 610 QILKWPQPWA 620 LGQVVTKTMV 630 NTVVANASFT 640 YLTALTDSNI VAIWGRM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005664 nuclear origin of replication recognition complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005721 pericentric heterochromatin
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0061628 histone H3K27me3 reader activity
Molecular Function GO:0008327 methyl-CpG binding
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0071169 establishment of protein localization to chromatin

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.