Search Results
Overview
| Uniprot ID | Q9UFE4 |
|---|---|
| Protein Name | Coiled-coil domain-containing protein 39 |
| Gene Name | CCDC39 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 684 | EGDCLDAKINKAEKE |
Function
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972)
Protein Sequence
10
MSSEFLAELH
20
WEDGFAIPVA
30
NEENKLLEDQ
40
LSKLKDERAS
50
LQDELREYEE
60
RINSMTSHFK
70
NVKQELSITQ
80
SLCKARERET
90
ESEEHFKAIA
100
QRELGRVKDE
110
IQRLENEMAS
120
ILEKKSDKEN
130
GIFKATQKLD
140
GLKCQMNWDQ
150
QALEAWLEES
160
AHKDSDALTL
170
QKYAQQDDNK
180
IRALTLQLER
190
LTLECNQKRK
200
ILDNELTETI
210
SAQLELDKAA
220
QDFRKIHNER
230
QELIKQWENT
240
IEQMQKRDGD
250
IDNCALELAR
260
IKQETREKEN
270
LVKEKIKFLE
280
SEIGNNTEFE
290
KRISVADRKL
300
LKCRTAYQDH
310
ETSRIQLKGE
320
LDSLKATVNR
330
TSSDLEALRK
340
NISKIKKDIH
350
EETARLQKTK
360
NHNEIIQTKL
370
KEITEKTMSV
380
EEKATNLEDM
390
LKEEEKDVKE
400
VDVQLNLIKG
410
VLFKKAQELQ
420
TETMKEKAVL
430
SEIEGTRSSL
440
KHLNHQLQKL
450
DFETLKQQEI
460
MYSQDFHIQQ
470
VERRMSRLKG
480
EINSEEKQAL
490
EAKIVELRKS
500
LEEKKSTCGL
510
LETQIKKLHN
520
DLYFIKKAHS
530
KNSDEKQSLM
540
TKINELNLFI
550
DRSEKELDKA
560
KGFKQDLMIE
570
DNLLKLEVKR
580
TREMLHSKAE
590
EVLSLEKRKQ
600
QLYTAMEERT
610
EEIKVHKTML
620
ASQIRYVDQE
630
RENISTEFRE
640
RLSKIEKLKN
650
RYEILTVVML
660
PPEGEEEKTQ
670
AYYVIKAAQE
680
KEELQREGDC
690
LDAKINKAEK
700
EIYALENTLQ
710
VLNSCNNNYK
720
QSFKKVTPSS
730
DEYELKIQLE
740
EQKRAVDEKY
750
RYKQRQIREL
760
QEDIQSMENT
770
LDVIEHLANN
780
VKEKLSEKQA
790
YSFQLSKETE
800
EQKPKLERVT
810
KQCAKLTKEI
820
RLLKDTKDET
830
MEEQDIKLRE
840
MKQFHKVIDE
850
MLVDIIEENT
860
EIRIILQTYF
870
QQSGLELPTA
880
STKGSRQSSR
890
SPSHTSLSAR
900
SSRSTSTSTS
910
QSSIKVLELK
920
FPASSSLVGS
930
PSRPSSASSS
940
SSNVKSKKSS
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0031514 | motile cilium |
| Biological Process | GO:0070286 | axonemal dynein complex assembly |
| Biological Process | GO:0003341 | cilium movement |
| Biological Process | GO:0044782 | cilium organization |
| Biological Process | GO:0060285 | cilium-dependent cell motility |
| Biological Process | GO:0071907 | determination of digestive tract left/right asymmetry |
| Biological Process | GO:0071910 | determination of liver left/right asymmetry |
| Biological Process | GO:0035469 | determination of pancreatic left/right asymmetry |
| Biological Process | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0001947 | heart looping |
| Biological Process | GO:0036159 | inner dynein arm assembly |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0044458 | motile cilium assembly |
| Biological Process | GO:0061512 | protein localization to cilium |
| Biological Process | GO:0003356 | regulation of cilium beat frequency |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.