Search Results

Overview

Uniprot IDQ9UFH2
Protein NameDynein axonemal heavy chain 17
Gene NameDNAH17
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
159 MSGKIKGKTLLPIPE
3949 RWLGTLDKKLEHYST

Function

Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum (By similarity). Produces force towards the minus ends of microtubules (By similarity). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required for structural and functional integrity of cilia (By similarity). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (PubMed:31178125)

Protein Sequence

10 MTMAPDVRLE 20 YLEEVASIVL 30 KFKPDKWSKL 40 IGAEENVALF 50 TEFFEKPDVQ 60 VLVLTLNAAG 70 MIIPCLGFPQ 80 SLKSKGVYFI 90 KTKSENINKD 100 NYRARLLYGD 110 ISPTPVDQLI 120 AVVEEVLSSL 130 LNQSENMAGW 140 PQVVSEDIVK 150 QVHRLKNEMF 160 VMSGKIKGKT 170 LLPIPEHLGS 180 LDGTLESMER 190 IPSSLDNLLL 200 HAIETTIIDW 210 SHQIRDVLSK 220 DSAQALLDGL 230 HPLPQVEFEF 240 WDTRLLNLKC 250 IHEQLNRPKV 260 NKIVEILEKA 270 KSCYWPALQN 280 VYTNVTEGLK 290 EANDIVLYLK 300 PLRILLEEME 310 QADFTMLPTF 320 IAKVLDTICF 330 IWATSEYYNT 340 PARIIVILQE 350 FCNQIIEMTR 360 TFLSPEEVLK 370 GLQGEIEEVL 380 SGISLAVNVL 390 KELYQTYDFC 400 CVNMKLFFKD 410 KEPVPWEFPS 420 SLAFSRINSF 430 FQRIQTIEEL 440 YKTAIEFLKL 450 EKIELGGVRG 460 NLLGSLVTRI 470 YDEVFELVKV 480 FADCKYDPLD 490 PGDSNFDRDY 500 ADFEIKIQDL 510 DRRLATIFCQ 520 GFDDCSCIKS 530 SAKLLYMCGG 540 LMERPLILAE 550 VAPRYSVMLE 560 LFDAELDNAK 570 ILYDAQMAAS 580 EEGNIPLIHK 590 NMPPVAGQLK 600 WSLELQERLE 610 VSMKHLKHVE 620 HPVMSGAEAK 630 LTYQKYDEMM 640 ELLRCHREKI 650 YQQWVAGVDQ 660 DCHFNLGQPL 670 ILRDAASNLI 680 HVNFSKALVA 690 VLREVKYLNF 700 QQQKEIPDSA 710 ESLFSENETF 720 RKFVGNLELI 730 VGWYNEIKTI 740 VKAVEFLLIK 750 SELEAIDVKL 760 LSAETTLFWN 770 GEGVFQYIQE 780 VREILHNLQN 790 RMQKAKQNIE 800 GISQAMKDWS 810 ANPLFERKDN 820 KKEALLDLDG 830 RIANLNKRYA 840 AVRDAGVKIQ 850 AMVAENAELF 860 RADTLSLPWK 870 DYVIYIDDMV 880 LDEFDQFIRK 890 SLSFLMDNMV 900 IDESIAPLFE 910 IRMELDEDGL 920 TFNPTLEVGS 930 DRGFLALIEG 940 LVNDIYNVAR 950 LIPRLAKDRM 960 NYKMDLEDNT 970 DLIEMREEVS 980 SLVINAMKEA 990 EEYQDSFERY 1000 SYLWTDNLQE 1010 FMKNFLIYGC 1020 AVTAEDLDTW 1030 TDDTIPKTPP 1040 TLAQFQEQID 1050 SYEKLYEEVS 1060 KCENTKVFHG 1070 WLQCDCRPFK 1080 QALLSTIRRW 1090 GFMFKRHLSN 1100 HVTNSLADLE 1110 AFMKVARMGL 1120 TKPLKEGDYD 1130 GLVEVMGHLM 1140 KVKERQAATD 1150 NMFEPLKQTI 1160 ELLKTYGEEM 1170 PEEIHLKLQE 1180 LPEHWANTKK 1190 LAIQVKLTVA 1200 PLQANEVSIL 1210 RRKCQQFELK 1220 QHEFRERFRR 1230 EAPFSFSDPN 1240 PYKSLNKQQK 1250 SISAMEGIME 1260 ALSKSGGLFE 1270 VPVPDYKQLK 1280 ACHREVRLLK 1290 ELWDMVVVVN 1300 TSIEDWKTTK 1310 WKDINVEQMD 1320 IDCKKFAKDM 1330 RSLDKEMKTW 1340 DAFVGLDNTV 1350 KNVITSLRAV 1360 SELQNPAIRE 1370 RHWQQLMQAT 1380 QVKFKMSEET 1390 TLADLLQLNL 1400 HSYEDEVRNI 1410 VDKAVKESGM 1420 EKVLKALDST 1430 WSMMEFQHEP 1440 HPRTGTMMLK 1450 SSEVLVETLE 1460 DNQVQLQNLM 1470 MSKYLAHFLK 1480 EVTSWQQKLS 1490 TADSVISIWF 1500 EVQRTWSHLE 1510 SIFIGSEDIR 1520 TQLPGDSQRF 1530 DDINQEFKAL 1540 MEDAVKTPNV 1550 VEATSKPGLY 1560 NKLEALKKSL 1570 AICEKALAEY 1580 LETKRLAFPR 1590 FYFVSSADLL 1600 DILSNGNDPV 1610 EVSRHLSKLF 1620 DSLCKLKFRL 1630 DASDKPLKVG 1640 LGMYSKEDEY 1650 MVFDQECDLS 1660 GQVEVWLNRV 1670 LDRMCSTLRH 1680 EIPEAVVTYE 1690 EKPREQWILD 1700 YPAQVALTCT 1710 QIWWTTEVGL 1720 AFARLEEGYE 1730 NAIRDYNKKQ 1740 ISQLNVLITL 1750 LMGNLNAGDR 1760 MKIMTICTID 1770 VHARDVVAKM 1780 IVAKVESSQA 1790 FTWQAQLRHR 1800 WDEEKRHCFA 1810 NICDAQIQYS 1820 YEYLGNTPRL 1830 VITPLTDRCY 1840 ITLTQSLHLI 1850 MGGAPAGPAG 1860 TGKTETTKDL 1870 GRALGTMVYV 1880 FNCSEQMDYK 1890 SCGNIYKGLA 1900 QTGAWGCFDE 1910 FNRISVEVLS 1920 VIAVQVKCVQ 1930 DAIRAKKKAF 1940 NFLGEIIGLI 1950 PTVGIFITMN 1960 PGYAGRAELP 1970 ENLKALFRPC 1980 AMVVPDFELI 1990 CEIMLMAEGF 2000 LEARLLARKF 2010 ITLYTLCKEL 2020 LSKQDHYDWG 2030 LRAIKSVLVV 2040 AGSLKRGDPS 2050 RAEDQVLMRA 2060 LRDFNIPKIV 2070 TDDLPVFMGL 2080 IGDLFPALDV 2090 PRKRDLNFEK 2100 IIKQSIVELK 2110 LQAEDSFVLK 2120 VVQLEELLQV 2130 RHSVFIVGNA 2140 GSGKSQVLKS 2150 LNKTYQNLKR 2160 KPVAVDLDPK 2170 AVTCDELFGI 2180 INPVTREWKD 2190 GLFSTIMRDL 2200 ANITHDGPKW 2210 IILDGDIDPM 2220 WIESLNTVMD 2230 DNKVLTLASN 2240 ERIPLNRTMR 2250 LVFEISHLRT 2260 ATPATVSRAG 2270 ILYINPADLG 2280 WNPVVSSWIE 2290 RRKVQSEKAN 2300 LMILFDKYLP 2310 TCLDKLRFGF 2320 KKITPVPEIT 2330 VIQTILYLLE 2340 CLLTEKTVPP 2350 DSPRELYELY 2360 FVFTCFWAFG 2370 GAMFQDQLVD 2380 YRVEFSKWWI 2390 NEFKTIKFPS 2400 QGTIFDYYID 2410 PDTKKFLPWT 2420 DKVPSFELDP 2430 DVPLQASLVH 2440 TTETIRIRYF 2450 MDLLMEKSWP 2460 VMLVGNAGTG 2470 KSVLMGDKLE 2480 SLNTDNYLVQ 2490 AVPFNFYTTS 2500 AMLQGVLEKP 2510 LEKKSGRNYG 2520 PPGTKKLVYF 2530 IDDMNMPEVD 2540 KYGTVAPHTL 2550 IRQHMDHRHW 2560 YDRHKLTLKD 2570 IHNCQYVACM 2580 NPTSGSFTID 2590 SRLQRHFCVF 2600 AVSFPGQEAL 2610 TTIYNTILTQ 2620 HLAFRSVSMA 2630 IQRISSQLVA 2640 AALALHQKIT 2650 ATFLPTAIKF 2660 HYVFNLRDLS 2670 NIFQGLLFST 2680 AEVLKTPLDL 2690 VRLWLHETER 2700 VYGDKMVDEK 2710 DQETLHRVTM 2720 ASTKKFFDDL 2730 GDELLFAKPN 2740 IFCHFAQGIG 2750 DPKYVPVTDM 2760 APLNKLLVDV 2770 LDSYNEVNAV 2780 MNLVLFEDAV 2790 AHICRINRIL 2800 ESPRGNALLV 2810 GVGGSGKQSL 2820 SRLAAYISGL 2830 DVFQITLKKG 2840 YGIPDLKIDL 2850 AAQYIKAAVK 2860 NVPSVFLMTD 2870 SQVAEEQFLV 2880 LINDLLASGE 2890 IPGLFMEDEV 2900 ENIISSMRPQ 2910 VKSLGMNDTR 2920 ETCWKFFIEK 2930 VRRQLKVILC 2940 FSPVGSVLRV 2950 RARKFPAVVN 2960 CTAIDWFHEW 2970 PEDALVSVSA 2980 RFLEETEGIP 2990 WEVKASISFF 3000 MSYVHTTVNE 3010 MSRVYLATER 3020 RYNYTTPKTF 3030 LEQIKLYQNL 3040 LAKKRTELVA 3050 KIERLENGLM 3060 KLQSTASQVD 3070 DLKAKLAIQE 3080 AELKQKNESA 3090 DQLIQVVGIE 3100 AEKVSKEKAI 3110 ADQEEVKVEV 3120 INKNVTEKQK 3130 ACETDLAKAE 3140 PALLAAQEAL 3150 DTLNKNNLTE 3160 LKSFGSPPDA 3170 VVNVTAAVMI 3180 LTAPGGKIPK 3190 DKSWKAAKIM 3200 MGKVDTFLDS 3210 LKKFDKEHIP 3220 EACLKAFKPY 3230 QGNPTFDPEF 3240 IRSKSTAAAG 3250 LCSWCINIVR 3260 FYEVYCDVAP 3270 KRQALEEANA 3280 ELAEAQEKLS 3290 RIKNKIAELN 3300 ANLSNLTSAF 3310 EKATAEKIKC 3320 QQEADATNRV 3330 ILLANRLVGG 3340 LASENIRWAE 3350 SVENFRSQGV 3360 TLCGDVLLIS 3370 AFVSYVGYFT 3380 KKYRNELMEK 3390 FWIPYIHNLK 3400 VPIPITNGLD 3410 PLSLLTDDAD 3420 VATWNNQGLP 3430 SDRMSTENAT 3440 ILGNTERWPL 3450 IVDAQLQGIK 3460 WIKNKYRSEL 3470 KAIRLGQKSY 3480 LDVIEQAISE 3490 GDTLLIENIG 3500 ETVDPVLDPL 3510 LGRNTIKKGK 3520 YIKIGDKEVE 3530 YHPKFRLILH 3540 TKYFNPHYKP 3550 EMQAQCTLIN 3560 FLVTRDGLED 3570 QLLAAVVAKE 3580 RPDLEQLKAN 3590 LTKSQNEFKI 3600 VLKELEDSLL 3610 ARLSAASGNF 3620 LGDTALVENL 3630 ETTKHTASEI 3640 EEKVVEAKIT 3650 EVKINEAREN 3660 YRPAAERASL 3670 LYFILNDLNK 3680 INPVYQFSLK 3690 AFNVVFEKAI 3700 QRTTPANEVK 3710 QRVINLTDEI 3720 TYSVYMYTAR 3730 GLFERDKLIF 3740 LAQVTFQVLS 3750 MKKELNPVEL 3760 DFLLRFPFKA 3770 GVVSPVDFLQ 3780 HQGWGGIKAL 3790 SEMDEFKNLD 3800 SDIEGSAKRW 3810 KKLVESEAPE 3820 KEIFPKEWKN 3830 KTALQKLCMV 3840 RCLRPDRMTY 3850 AIKNFVEEKM 3860 GSKFVEGRSV 3870 EFSKSYEESS 3880 PSTSIFFILS 3890 PGVDPLKDVE 3900 ALGKKLGFTI 3910 DNGKLHNVSL 3920 GQGQEVVAEN 3930 ALDVAAEKGH 3940 WVILQNIHLV 3950 ARWLGTLDKK 3960 LEHYSTGSHE 3970 DYRVFISAEP 3980 APSPETHIIP 3990 QGILENAIKI 4000 TNEPPTGMHA 4010 NLHKALDLFT 4020 QDTLEMCTKE 4030 MEFKCMLFAL 4040 CYFHAVVAER 4050 RKFGAQGWNR 4060 SYPFNNGDLT 4070 ISINVLYNYL 4080 EANPKVPWDD 4090 LRYLFGEIMY 4100 GGHITDDWDR 4110 RLCRTYLAEY 4120 IRTEMLEGDV 4130 LLAPGFQIPP 4140 NLDYKGYHEY 4150 IDENLPPESP 4160 YLYGLHPNAE 4170 IGFLTVTSEK 4180 LFRTVLEMQP 4190 KETDSGAGTG 4200 VSREEKVKAV 4210 LDDILEKIPE 4220 TFNMAEIMAK 4230 AAEKTPYVVV 4240 AFQECERMNI 4250 LTNEMRRSLK 4260 ELNLGLKGEL 4270 TITTDVEDLS 4280 TALFYDTVPD 4290 TWVARAYPSM 4300 MGLAAWYADL 4310 LLRIRELEAW 4320 TTDFALPTTV 4330 WLAGFFNPQS 4340 FLTAIMQSMA 4350 RKNEWPLDKM 4360 CLSVEVTKKN 4370 REDMTAPPRE 4380 GSYVYGLFME 4390 GARWDTQTGV 4400 IAEARLKELT 4410 PAMPVIFIKA 4420 IPVDRMETKN 4430 IYECPVYKTR 4440 IRGPTYVWTF 4450 NLKTKEKAAK 4460 WILAAVALLL QV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097729 9+2 motile cilium
Cellular Component GO:0005858 axonemal dynein complex
Cellular Component GO:0005930 axoneme
Cellular Component GO:0030286 dynein complex
Cellular Component GO:0005874 microtubule
Cellular Component GO:0036157 outer dynein arm
Cellular Component GO:0097229 sperm end piece
Cellular Component GO:0036126 sperm flagellum
Cellular Component GO:0097225 sperm midpiece
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0003777 microtubule motor activity
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Biological Process GO:0060294 cilium movement involved in cell motility
Biological Process GO:0060285 cilium-dependent cell motility
Biological Process GO:0036158 outer dynein arm assembly

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.