Search Results

Overview

Uniprot ID	Q9UFW8
Protein Name	CGG triplet repeat-binding protein 1
Gene Name	CGGBP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
16	PPARNRSKTALYVTP
71	SKTHTKRKAEFEEQN
82	EEQNVRKKQRPLTAS

Function

Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter

Protein Sequence

10 MERFVVTAPP 20 ARNRSKTALY 30 VTPLDRVTEF 40 GGELHEDGGK 50 LFCTSCNVVL 60 NHVRKSAISD 70 HLKSKTHTKR 80 KAEFEEQNVR 90 KKQRPLTASL 100 QCNSTAQTEK 110 VSVIQDFVKM 120 CLEANIPLEK 130 ADHPAVRAFL 140 SRHVKNGGSI 150 PKSDQLRRAY 160 LPDGYENENQ LLNSQDC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0003690	double-stranded DNA binding
Molecular Function	GO:0042802	identical protein binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0040029	epigenetic regulation of gene expression
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0010468	regulation of gene expression

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.