Search Results
Overview
| Uniprot ID | Q9UG56 |
|---|---|
| Protein Name | Phosphatidylserine decarboxylase proenzyme, mitochondrial |
| Gene Name | PISD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 201 | ILNFGQVKNCEVEQV |
Function
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (PubMed:30488656, PubMed:30858161). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity)
Protein Sequence
10
MATSVGHRCL
20
GLLHGVAPWR
30
SSLHPCEITA
40
LSQSLQPLRK
50
LPFRAFRTDA
60
RKIHTAPART
70
MFLLRPLPIL
80
LVTGGGYAGY
90
RQYEKYRERE
100
LEKLGLEIPP
110
KLAGHWEVAL
120
YKSVPTRLLS
130
RAWGRLNQVE
140
LPHWLRRPVY
150
SLYIWTFGVN
160
MKEAAVEDLH
170
HYRNLSEFFR
180
RKLKPQARPV
190
CGLHSVISPS
200
DGRILNFGQV
210
KNCEVEQVKG
220
VTYSLESFLG
230
PRMCTEDLPF
240
PPAASCDSFK
250
NQLVTREGNE
260
LYHCVIYLAP
270
GDYHCFHSPT
280
DWTVSHRRHF
290
PGSLMSVNPG
300
MARWIKELFC
310
HNERVVLTGD
320
WKHGFFSLTA
330
VGATNVGSIR
340
IYFDRDLHTN
350
SPRHSKGSYN
360
DFSFVTHTNR
370
EGVPMRKGEH
380
LGEFNLGSTI
390
VLIFEAPKDF
400
NFQLKTGQKI
RFGEALGSL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004609 | phosphatidylserine decarboxylase activity |
| Biological Process | GO:0140042 | lipid droplet formation |
| Biological Process | GO:0035694 | mitochondrial protein catabolic process |
| Biological Process | GO:0006646 | phosphatidylethanolamine biosynthetic process |
| Biological Process | GO:0016540 | protein autoprocessing |
| Biological Process | GO:0010821 | regulation of mitochondrion organization |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.