Search Results

Overview

Uniprot IDQ9UGI8
Protein NameTestin
Gene NameTES
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 LTNPVAAKKNVSINT
102 TNPVAAKKNVSINTV
163 AHDQDPSKCHELSPR
183 EQFVKKYKSEALGVG
193 ALGVGDVKLPCEMDA
225 AVGAMEDKSAEHKRT
6 **MDLENKVKKMGLG
78 KYTTLIAKLKSDGIP
80 TTLIAKLKSDGIPMY
9 DLENKVKKMGLGHEQ

Function

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth

Protein Sequence

10 MDLENKVKKM 20 GLGHEQGFGA 30 PCLKCKEKCE 40 GFELHFWRKI 50 CRNCKCGQEE 60 HDVLLSNEED 70 RKVGKLFEDT 80 KYTTLIAKLK 90 SDGIPMYKRN 100 VMILTNPVAA 110 KKNVSINTVT 120 YEWAPPVQNQ 130 ALARQYMQML 140 PKEKQPVAGS 150 EGAQYRKKQL 160 AKQLPAHDQD 170 PSKCHELSPR 180 EVKEMEQFVK 190 KYKSEALGVG 200 DVKLPCEMDA 210 QGPKQMNIPG 220 GDRSTPAAVG 230 AMEDKSAEHK 240 RTQYSCYCCK 250 LSMKEGDPAI 260 YAERAGYDKL 270 WHPACFVCST 280 CHELLVDMIY 290 FWKNEKLYCG 300 RHYCDSEKPR 310 CAGCDELIFS 320 NEYTQAENQN 330 WHLKHFCCFD 340 CDSILAGEIY 350 VMVNDKPVCK 360 PCYVKNHAVV 370 CQGCHNAIDP 380 EVQRVTYNNF 390 SWHASTECFL 400 CSCCSKCLIG 410 QKFMPVEGMV 420 FCSVECKKRM S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0008285 negative regulation of cell population proliferation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.