Search Results

Overview

Uniprot ID	Q9UGL1
Protein Name	Lysine-specific demethylase 5B
Gene Name	KDM5B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1439	TPKKKKIKLSHPKDM

Function

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity)

Protein Sequence

10 MEAATTLHPG 20 PRPALPLGGP 30 GPLGEFLPPP 40 ECPVFEPSWE 50 EFADPFAFIH 60 KIRPIAEQTG 70 ICKVRPPPDW 80 QPPFACDVDK 90 LHFTPRIQRL 100 NELEAQTRVK 110 LNFLDQIAKY 120 WELQGSTLKI 130 PHVERKILDL 140 FQLNKLVAEE 150 GGFAVVCKDR 160 KWTKIATKMG 170 FAPGKAVGSH 180 IRGHYERILN 190 PYNLFLSGDS 200 LRCLQKPNLT 210 TDTKDKEYKP 220 HDIPQRQSVQ 230 PSETCPPARR 240 AKRMRAEAMN 250 IKIEPEETTE 260 ARTHNLRRRM 270 GCPTPKCENE 280 KEMKSSIKQE 290 PIERKDYIVE 300 NEKEKPKSRS 310 KKATNAVDLY 320 VCLLCGSGND 330 EDRLLLCDGC 340 DDSYHTFCLI 350 PPLHDVPKGD 360 WRCPKCLAQE 370 CSKPQEAFGF 380 EQAARDYTLR 390 TFGEMADAFK 400 SDYFNMPVHM 410 VPTELVEKEF 420 WRLVSTIEED 430 VTVEYGADIA 440 SKEFGSGFPV 450 RDGKIKLSPE 460 EEEYLDSGWN 470 LNNMPVMEQS 480 VLAHITADIC 490 GMKLPWLYVG 500 MCFSSFCWHI 510 EDHWSYSINY 520 LHWGEPKTWY 530 GVPGYAAEQL 540 ENVMKKLAPE 550 LFVSQPDLLH 560 QLVTIMNPNT 570 LMTHEVPVYR 580 TNQCAGEFVI 590 TFPRAYHSGF 600 NQGFNFAEAV 610 NFCTVDWLPL 620 GRQCVEHYRL 630 LHRYCVFSHD 640 EMICKMASKA 650 DVLDVVVAST 660 VQKDMAIMIE 670 DEKALRETVR 680 KLGVIDSERM 690 DFELLPDDER 700 QCVKCKTTCF 710 MSAISCSCKP 720 GLLVCLHHVK 730 ELCSCPPYKY 740 KLRYRYTLDD 750 LYPMMNALKL 760 RAESYNEWAL 770 NVNEALEAKI 780 NKKKSLVSFK 790 ALIEESEMKK 800 FPDNDLLRHL 810 RLVTQDAEKC 820 ASVAQQLLNG 830 KRQTRYRSGG 840 GKSQNQLTVN 850 ELRQFVTQLY 860 ALPCVLSQTP 870 LLKDLLNRVE 880 DFQQHSQKLL 890 SEETPSAAEL 900 QDLLDVSFEF 910 DVELPQLAEM 920 RIRLEQARWL 930 EEVQQACLDP 940 SSLTLDDMRR 950 LIDLGVGLAP 960 YSAVEKAMAR 970 LQELLTVSEH 980 WDDKAKSLLK 990 ARPRHSLNSL 1000 ATAVKEIEEI 1010 PAYLPNGAAL 1020 KDSVQRARDW 1030 LQDVEGLQAG 1040 GRVPVLDTLI 1050 ELVTRGRSIP 1060 VHLNSLPRLE 1070 TLVAEVQAWK 1080 ECAVNTFLTE 1090 NSPYSLLEVL 1100 CPRCDIGLLG 1110 LKRKQRKLKE 1120 PLPNGKKKST 1130 KLESLSDLER 1140 ALTESKETAS 1150 AMATLGEARL 1160 REMEALQSLR 1170 LANEGKLLSP 1180 LQDVDIKICL 1190 CQKAPAAPMI 1200 QCELCRDAFH 1210 TSCVAVPSIS 1220 QGLRIWLCPH 1230 CRRSEKPPLE 1240 KILPLLASLQ 1250 RIRVRLPEGD 1260 ALRYMIERTV 1270 NWQHRAQQLL 1280 SSGNLKFVQD 1290 RVGSGLLYSR 1300 WQASAGQVSD 1310 TNKVSQPPGT 1320 TSFSLPDDWD 1330 NRTSYLHSPF 1340 STGRSCIPLH 1350 GVSPEVNELL 1360 MEAQLLQVSL 1370 PEIQELYQTL 1380 LAKPSPAQQT 1390 DRSSPVRPSS 1400 EKNDCCRGKR 1410 DGINSLERKL 1420 KRRLEREGLS 1430 SERWERVKKM 1440 RTPKKKKIKL 1450 SHPKDMNNFK 1460 LERERSYELV 1470 RSAETHSLPS 1480 DTSYSEQEDS 1490 EDEDAICPAV 1500 SCLQPEGDEV 1510 DWVQCDGSCN 1520 QWFHQVCVGV 1530 SPEMAEKEDY 1540 ICVRCTVKDA PSRK

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0003676	nucleic acid binding
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding
Molecular Function	GO:0003714	transcription corepressor activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0070306	lens fiber cell differentiation
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0060992	response to fungicide
Biological Process	GO:0048511	rhythmic process
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0042393	histone binding
Molecular Function	GO:0032452	histone demethylase activity
Molecular Function	GO:0032453	histone H3K4 demethylase activity
Molecular Function	GO:0034647	histone H3K4me/H3K4me2/H3K4me3 demethylase activity

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.