Search Results
Overview
| Uniprot ID | Q9UGM6 |
|---|---|
| Protein Name | Tryptophan--tRNA ligase, mitochondrial |
| Gene Name | WARS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 143 | LQHLHQWKAKTTKQK |
| 253 | EIVQKFRKAVTDFTS |
Function
Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp)
Protein Sequence
10
MALHSMRKAR
20
ERWSFIRALH
30
KGSAAAPALQ
40
KDSKKRVFSG
50
IQPTGILHLG
60
NYLGAIESWV
70
RLQDEYDSVL
80
YSIVDLHSIT
90
VPQDPAVLRQ
100
SILDMTAVLL
110
ACGINPEKSI
120
LFQQSQVSEH
130
TQLSWILSCM
140
VRLPRLQHLH
150
QWKAKTTKQK
160
HDGTVGLLTY
170
PVLQAADILL
180
YKSTHVPVGE
190
DQVQHMELVQ
200
DLAQGFNKKY
210
GEFFPVPESI
220
LTSMKKVKSL
230
RDPSAKMSKS
240
DPDKLATVRI
250
TDSPEEIVQK
260
FRKAVTDFTS
270
EVTYDPAGRA
280
GVSNIVAVHA
290
AVTGLSVEEV
300
VRRSAGMNTA
310
RYKLAVADAV
320
IEKFAPIKRE
330
IEKLKLDKDH
340
LEKVLQIGSA
350
KAKELAYTVC
360
QEVKKLVGFL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004830 | tryptophan-tRNA ligase activity |
| Biological Process | GO:0070183 | mitochondrial tryptophanyl-tRNA aminoacylation |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.