Search Results

Overview

Uniprot IDQ9UGP8
Protein NameTranslocation protein SEC63 homolog
Gene NameSEC63
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
287 EIGSINLKKNEPPLT
416 IQDLVSLKESDRHTL
485 TMAEVFEKEQSICAA
516 TKGGWQQKSKGPKKT

Function

Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity)

Protein Sequence

10 MAGQQFQYDD 20 SGNTFFYFLT 30 SFVGLIVIPA 40 TYYLWPRDQN 50 AEQIRLKNIR 60 KVYGRCMWYR 70 LRLLKPQPNI 80 IPTVKKIVLL 90 AGWALFLFLA 100 YKVSKTDREY 110 QEYNPYEVLN 120 LDPGATVAEI 130 KKQYRLLSLK 140 YHPDKGGDEV 150 MFMRIAKAYA 160 ALTDEESRKN 170 WEEFGNPDGP 180 QATSFGIALP 190 AWIVDQKNSI 200 LVLLVYGLAF 210 MVILPVVVGS 220 WWYRSIRYSG 230 DQILIRTTQI 240 YTYFVYKTRN 250 MDMKRLIMVL 260 AGASEFDPQY 270 NKDATSRPTD 280 NILIPQLIRE 290 IGSINLKKNE 300 PPLTCPYSLK 310 ARVLLLSHLA 320 RMKIPETLEE 330 DQQFMLKKCP 340 ALLQEMVNVI 350 CQLIVMARNR 360 EEREFRAPTL 370 ASLENCMKLS 380 QMAVQGLQQF 390 KSPLLQLPHI 400 EEDNLRRVSN 410 HKKYKIKTIQ 420 DLVSLKESDR 430 HTLLHFLEDE 440 KYEEVMAVLG 450 SFPYVTMDIK 460 SQVLDDEDSN 470 NITVGSLVTV 480 LVKLTRQTMA 490 EVFEKEQSIC 500 AAEEQPAEDG 510 QGETNKNRTK 520 GGWQQKSKGP 530 KKTAKSKKKK 540 PLKKKPTPVL 550 LPQSKQQKQK 560 QANGVVGNEA 570 AVKEDEEEVS 580 DKGSDSEEEE 590 TNRDSQSEKD 600 DGSDRDSDRE 610 QDEKQNKDDE 620 AEWQELQQSI 630 QRKERALLET 640 KSKITHPVYS 650 LYFPEEKQEW 660 WWLYIADRKE 670 QTLISMPYHV 680 CTLKDTEEVE 690 LKFPAPGKPG 700 NYQYTVFLRS 710 DSYMGLDQIK 720 PLKLEVHEAK 730 PVPENHPQWD 740 TAIEGDEDQE 750 DSEGFEDSFE 760 EEEEEEEDDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0016020 membrane
Cellular Component GO:0031207 Sec62/Sec63 complex
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0038023 signaling receptor activity
Biological Process GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
Biological Process GO:0031204 post-translational protein targeting to membrane, translocation
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.