Search Results

Overview

Uniprot IDQ9UGU0
Protein NameTranscription factor 20
Gene NameTCF20
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1015 QYHDFAEKLKMSPGR
1086 LNSQLHYKRQMYQQQ
1121 HRQEGPRKSPRQQQF
1173 SSDGLPNKGMELKHG
1178 PNKGMELKHGSQKLQ
1183 ELKHGSQKLQESCWD
1267 FISPIPSKRQSQDVK
1294 SSKEGADKAFNSYAH
1340 LTSPAKTKILPPRKG
1351 PRKGRGLKLEAIVQK
1358 KLEAIVQKITSPNIR
1538 KGYFPSGKKKGRPIG
1735 DYAATLPKNPPPKRA
602 GNPKVNEKTVGVIVS
710 GSLRYSYKDSFGSAV
844 TDYPIPRKFEIEPQS
922 VSMETKLKSQSGQIK
945 SQASFNNKKSGDHCH

Function

Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator

Protein Sequence

10 MQSFREQSSY 20 HGNQQSYPQE 30 VHGSSRLEEF 40 SPRQAQMFQN 50 FGGTGGSSGS 60 SGSGSGGGRR 70 GAAAAAAAMA 80 SETSGHQGYQ 90 GFRKEAGDFY 100 YMAGNKDPVT 110 TGTPQPPQRR 120 PSGPVQSYGP 130 PQGSSFGNQY 140 GSEGHVGQFQ 150 AQHSGLGGVS 160 HYQQDYTGPF 170 SPGSAQYQQQ 180 ASSQQQQQQV 190 QQLRQQLYQS 200 HQPLPQATGQ 210 PASSSSHLQP 220 MQRPSTLPSS 230 AAGYQLRVGQ 240 FGQHYQSSAS 250 SSSSSSFPSP 260 QRFSQSGQSY 270 DGSYNVNAGS 280 QYEGHNVGSN 290 AQAYGTQSNY 300 SYQPQSMKNF 310 EQAKIPQGTQ 320 QGQQQQQPQQ 330 QQHPSQHVMQ 340 YTNAATKLPL 350 QSQVGQYNQP 360 EVPVRSPMQF 370 HQNFSPISNP 380 SPAASVVQSP 390 SCSSTPSPLM 400 QTGENLQCGQ 410 GSVPMGSRNR 420 ILQLMPQLSP 430 TPSMMPSPNS 440 HAAGFKGFGL 450 EGVPEKRLTD 460 PGLSSLSALS 470 TQVANLPNTV 480 QHMLLSDALT 490 PQKKTSKRPS 500 SSKKADSCTN 510 SEGSSQPEEQ 520 LKSPMAESLD 530 GGCSSSSEDQ 540 GERVRQLSGQ 550 STSSDTTYKG 560 GASEKAGSSP 570 AQGAQNEPPR 580 LNASPAAREE 590 ATSPGAKDMP 600 LSSDGNPKVN 610 EKTVGVIVSR 620 EAMTGRVEKP 630 GGQDKGSQED 640 DPAATQRPPS 650 NGGAKETSHA 660 SLPQPEPPGG 670 GGSKGNKNGD 680 NNSNHNGEGN 690 GQSGHSAAGP 700 GFTSRTEPSK 710 SPGSLRYSYK 720 DSFGSAVPRN 730 VSGFPQYPTG 740 QEKGDFTGHG 750 ERKGRNEKFP 760 SLLQEVLQGY 770 HHHPDRRYSR 780 STQEHQGMAG 790 SLEGTTRPNV 800 LVSQTNELAS 810 RGLLNKSIGS 820 LLENPHWGPW 830 ERKSSSTAPE 840 MKQINLTDYP 850 IPRKFEIEPQ 860 SSAHEPGGSL 870 SERRSVICDI 880 SPLRQIVRDP 890 GAHSLGHMSA 900 DTRIGRNDRL 910 NPTLSQSVIL 920 PGGLVSMETK 930 LKSQSGQIKE 940 EDFEQSKSQA 950 SFNNKKSGDH 960 CHPPSIKHES 970 YRGNASPGAA 980 THDSLSDYGP 990 QDSRPTPMRR 1000 VPGRVGGREG 1010 MRGRSPSQYH 1020 DFAEKLKMSP 1030 GRSRGPGGDP 1040 HHMNPHMTFS 1050 ERANRSSLHT 1060 PFSPNSETLA 1070 SAYHANTRAH 1080 AYGDPNAGLN 1090 SQLHYKRQMY 1100 QQQPEEYKDW 1110 SSGSAQGVIA 1120 AAQHRQEGPR 1130 KSPRQQQFLD 1140 RVRSPLKNDK 1150 DGMMYGPPVG 1160 TYHDPSAQEA 1170 GRCLMSSDGL 1180 PNKGMELKHG 1190 SQKLQESCWD 1200 LSRQTSPAKS 1210 SGPPGMSSQK 1220 RYGPPHETDG 1230 HGLAEATQSS 1240 KPGSVMLRLP 1250 GQEDHSSQNP 1260 LIMRRRVRSF 1270 ISPIPSKRQS 1280 QDVKNSSTED 1290 KGRLLHSSKE 1300 GADKAFNSYA 1310 HLSHSQDIKS 1320 IPKRDSSKDL 1330 PSPDSRNCPA 1340 VTLTSPAKTK 1350 ILPPRKGRGL 1360 KLEAIVQKIT 1370 SPNIRRSASS 1380 NSAEAGGDTV 1390 TLDDILSLKS 1400 GPPEGGSVAV 1410 QDADIEKRKG 1420 EVASDLVSPA 1430 NQELHVEKPL 1440 PRSSEEWRGS 1450 VDDKVKTETH 1460 AETVTAGKEP 1470 PGAMTSTTSQ 1480 KPGSNQGRPD 1490 GSLGGTAPLI 1500 FPDSKNVPPV 1510 GILAPEANPK 1520 AEEKENDTVT 1530 ISPKQEGFPP 1540 KGYFPSGKKK 1550 GRPIGSVNKQ 1560 KKQQQPPPPP 1570 PQPPQIPEGS 1580 ADGEPKPKKQ 1590 RQRRERRKPG 1600 AQPRKRKTKQ 1610 AVPIVEPQEP 1620 EIKLKYATQP 1630 LDKTDAKNKS 1640 FYPYIHVVNK 1650 CELGAVCTII 1660 NAEEEEQTKL 1670 VRGRKGQRSL 1680 TPPPSSTESK 1690 ALPASSFMLQ 1700 GPVVTESSVM 1710 GHLVCCLCGK 1720 WASYRNMGDL 1730 FGPFYPQDYA 1740 ATLPKNPPPK 1750 RATEMQSKVK 1760 VRHKSASNGS 1770 KTDTEEEEEQ 1780 QQQQKEQRSL 1790 AAHPRFKRRH 1800 RSEDCGGGPR 1810 SLSRGLPCKK 1820 AATEGSSEKT 1830 VLDSKPSVPT 1840 TSEGGPELEL 1850 QIPELPLDSN 1860 EFWVHEGCIL 1870 WANGIYLVCG 1880 RLYGLQEALE 1890 IAREMKCSHC 1900 QEAGATLGCY 1910 NKGCSFRYHY 1920 PCAIDADCLL 1930 HEENFSVRCP 1940 KHKPPLPCPL 1950 PPLQNKTAKG 1960 SLSTEQSERG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.