Search Results
Overview
| Uniprot ID | Q9UGY1 |
|---|---|
| Protein Name | Nucleolar protein 12 |
| Gene Name | NOL12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | SSTEKPTKALPRKSR |
Function
Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155)
Protein Sequence
10
MGRNKKKKRD
20
GDDRRPRLVL
30
SFDEEKRREY
40
LTGFHKRKVE
50
RKKAAIEEIK
60
QRLKEEQRKL
70
REERHQEYLK
80
MLAEREEALE
90
EADELDRLVT
100
AKTESVQYDH
110
PNHTVTVTTI
120
SDLDLSGARL
130
LGLTPPEGGA
140
GDRSEEEASS
150
TEKPTKALPR
160
KSRDPLLSQR
170
ISSLTASLHA
180
HSRKKVKRKH
190
PRRAQDSKKP
200
PRAPRTSKAQ
210
RRRLTGKARH
SGE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005730 | nucleolus |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0019843 | rRNA binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
Reference
PMID: N/A