Search Results
Overview
| Uniprot ID | Q9UHD0 |
|---|---|
| Protein Name | Interleukin-19 |
| Gene Name | IL19 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | NSFLYMQKTLRQCQE |
Function
Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624). In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763)
Protein Sequence
10
MKLQCVSLWL
20
LGTILILCSV
30
DNHGLRRCLI
40
STDMHHIEES
50
FQEIKRAIQA
60
KDTFPNVTIL
70
STLETLQIIK
80
PLDVCCVTKN
90
LLAFYVDRVF
100
KDHQEPNPKI
110
LRKISSIANS
120
FLYMQKTLRQ
130
CQEQRQCHCR
140
QEATNATRVI
150
HDNYDQLEVH
160
AAAIKSLGEL
170
DVFLAWINKN
HEVMFSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005125 | cytokine activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0010989 | negative regulation of low-density lipoprotein particle clearance |
| Biological Process | GO:0007165 | signal transduction |
Reference
PMID: N/A