Search Results

Overview

Uniprot IDQ9UHD8
Protein NameSeptin-9
Gene NameSEPTIN9
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
141 RAEVLGHKTPEPAPR
156 RTEITIVKPQESAHR
186 PATDAAPKRVEIQMP
262 TPRDAGLKQAPASRN
28 DSSGPALKRSFEVEE
3 *****MKKSYSGGTR
326 FKSKISRKSVQPTSE
343 IPKTIEIKSITHDIE
352 ITHDIEEKGVRMKLT
62 TVASSTQKFQDLGVK
69 KFQDLGVKNSEPSAR
99 RVELSGPKAAEPVSR

Function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri

Protein Sequence

10 MKKSYSGGTR 20 TSSGRLRRLG 30 DSSGPALKRS 40 FEVEEVETPN 50 STPPRRVQTP 60 LLRATVASST 70 QKFQDLGVKN 80 SEPSARHVDS 90 LSQRSPKASL 100 RRVELSGPKA 110 AEPVSRRTEL 120 SIDISSKQVE 130 NAGAIGPSRF 140 GLKRAEVLGH 150 KTPEPAPRRT 160 EITIVKPQES 170 AHRRMEPPAS 180 KVPEVPTAPA 190 TDAAPKRVEI 200 QMPKPAEAPT 210 APSPAQTLEN 220 SEPAPVSQLQ 230 SRLEPKPQPP 240 VAEATPRSQE 250 ATEAAPSCVG 260 DMADTPRDAG 270 LKQAPASRNE 280 KAPVDFGYVG 290 IDSILEQMRR 300 KAMKQGFEFN 310 IMVVGQSGLG 320 KSTLINTLFK 330 SKISRKSVQP 340 TSEERIPKTI 350 EIKSITHDIE 360 EKGVRMKLTV 370 IDTPGFGDHI 380 NNENCWQPIM 390 KFINDQYEKY 400 LQEEVNINRK 410 KRIPDTRVHC 420 CLYFIPATGH 430 SLRPLDIEFM 440 KRLSKVVNIV 450 PVIAKADTLT 460 LEERVHFKQR 470 ITADLLSNGI 480 DVYPQKEFDE 490 DSEDRLVNEK 500 FREMIPFAVV 510 GSDHEYQVNG 520 KRILGRKTKW 530 GTIEVENTTH 540 CEFAYLRDLL 550 IRTHMQNIKD 560 ITSSIHFEAY 570 RVKRLNEGSS 580 AMANGMEEKE PEAPEM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005930 axoneme
Cellular Component GO:0032153 cell division site
Cellular Component GO:0005929 cilium
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0045171 intercellular bridge
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0097730 non-motile cilium
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0031105 septin complex
Cellular Component GO:0005940 septin ring
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0060090 molecular adaptor activity
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0061640 cytoskeleton-dependent cytokinesis
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:1902857 positive regulation of non-motile cilium assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.