Search Results

Overview

Uniprot IDQ9UHF7
Protein NameZinc finger transcription factor Trps1
Gene NameTRPS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1003 IPLPSLSKYEAQGSL
29 EPIGTESKVSGKNKE
381 PSEKNSNKSIPALQS

Function

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes

Protein Sequence

10 MVRKKNPPLR 20 NVASEGEGQI 30 LEPIGTESKV 40 SGKNKEFSAD 50 QMSENTDQSD 60 AAELNHKEEH 70 SLHVQDPSSS 80 SKKDLKSAVL 90 SEKAGFNYES 100 PSKGGNFPSF 110 PHDEVTDRNM 120 LAFSSPAAGG 130 VCEPLKSPQR 140 AEADDPQDMA 150 CTPSGDSLET 160 KEDQKMSPKA 170 TEETGQAQSG 180 QANCQGLSPV 190 SVASKNPQVP 200 SDGGVRLNKS 210 KTDLLVNDNP 220 DPAPLSPELQ 230 DFKCNICGYG 240 YYGNDPTDLI 250 KHFRKYHLGL 260 HNRTRQDAEL 270 DSKILALHNM 280 VQFSHSKDFQ 290 KVNRSVFSGV 300 LQDINSSRPV 310 LLNGTYDVQV 320 TSGGTFIGIG 330 RKTPDCQGNT 340 KYFRCKFCNF 350 TYMGNSSTEL 360 EQHFLQTHPN 370 KIKASLPSSE 380 VAKPSEKNSN 390 KSIPALQSSD 400 SGDLGKWQDK 410 ITVKAGDDTP 420 VGYSVPIKPL 430 DSSRQNGTEA 440 TSYYWCKFCS 450 FSCESSSSLK 460 LLEHYGKQHG 470 AVQSGGLNPE 480 LNDKLSRGSV 490 INQNDLAKSS 500 EGETMTKTDK 510 SSSGAKKKDF 520 SSKGAEDNMV 530 TSYNCQFCDF 540 RYSKSHGPDV 550 IVVGPLLRHY 560 QQLHNIHKCT 570 IKHCPFCPRG 580 LCSPEKHLGE 590 ITYPFACRKS 600 NCSHCALLLL 610 HLSPGAAGSS 620 RVKHQCHQCS 630 FTTPDVDVLL 640 FHYESVHESQ 650 ASDVKQEANH 660 LQGSDGQQSV 670 KESKEHSCTK 680 CDFITQVEEE 690 ISRHYRRAHS 700 CYKCRQCSFT 710 AADTQSLLEH 720 FNTVHCQEQD 730 ITTANGEEDG 740 HAISTIKEEP 750 KIDFRVYNLL 760 TPDSKMGEPV 770 SESVVKREKL 780 EEKDGLKEKV 790 WTESSSDDLR 800 NVTWRGADIL 810 RGSPSYTQAS 820 LGLLTPVSGT 830 QEQTKTLRDS 840 PNVEAAHLAR 850 PIYGLAVETK 860 GFLQGAPAGG 870 EKSGALPQQY 880 PASGENKSKD 890 ESQSLLRRRR 900 GSGVFCANCL 910 TTKTSLWRKN 920 ANGGYVCNAC 930 GLYQKLHSTP 940 RPLNIIKQNN 950 GEQIIRRRTR 960 KRLNPEALQA 970 EQLNKQQRGS 980 NEEQVNGSPL 990 ERRSEDHLTE 1000 SHQREIPLPS 1010 LSKYEAQGSL 1020 TKSHSAQQPV 1030 LVSQTLDIHK 1040 RMQPLHIQIK 1050 SPQESTGDPG 1060 NSSSVSEGKG 1070 SSERGSPIEK 1080 YMRPAKHPNY 1090 SPPGSPIEKY 1100 QYPLFGLPFV 1110 HNDFQSEADW 1120 LRFWSKYKLS 1130 VPGNPHYLSH 1140 VPGLPNPCQN 1150 YVPYPTFNLP 1160 PHFSAVGSDN 1170 DIPLDLAIKH 1180 SRPGPTANGA 1190 SKEKTKAPPN 1200 VKNEGPLNVV 1210 KTEKVDRSTQ 1220 DELSTKCVHC 1230 GIVFLDEVMY 1240 ALHMSCHGDS 1250 GPFQCSICQH 1260 LCTDKYDFTT 1270 HIQRGLHRNN 1280 AQVEKNGKPK E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0032330 regulation of chondrocyte differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0001501 skeletal system development

Reference

PMID: N/A