Search Results

Overview

Uniprot ID	Q9UHG3
Protein Name	Prenylcysteine oxidase 1
Gene Name	PCYOX1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
415	FSQETLTKAQILKLF

Function

Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:10585463)

Protein Sequence

10 MGRVVAELVS 20 SLLGLWLLLC 30 SCGCPEGAEL 40 RAPPDKIAII 50 GAGIGGTSAA 60 YYLRQKFGKD 70 VKIDLFEREE 80 VGGRLATMMV 90 QGQEYEAGGS 100 VIHPLNLHMK 110 RFVKDLGLSA 120 VQASGGLLGI 130 YNGETLVFEE 140 SNWFIINVIK 150 LVWRYGFQSL 160 RMHMWVEDVL 170 DKFMRIYRYQ 180 SHDYAFSSVE 190 KLLHALGGDD 200 FLGMLNRTLL 210 ETLQKAGFSE 220 KFLNEMIAPV 230 MRVNYGQSTD 240 INAFVGAVSL 250 SCSDSGLWAV 260 EGGNKLVCSG 270 LLQASKSNLI 280 SGSVMYIEEK 290 TKTKYTGNPT 300 KMYEVVYQIG 310 TETRSDFYDI 320 VLVATPLNRK 330 MSNITFLNFD 340 PPIEEFHQYY 350 QHIVTTLVKG 360 ELNTSIFSSR 370 PIDKFGLNTV 380 LTTDNSDLFI 390 NSIGIVPSVR 400 EKEDPEPSTD 410 GTYVWKIFSQ 420 ETLTKAQILK 430 LFLSYDYAVK 440 KPWLAYPHYK 450 PPEKCPSIIL 460 HDRLYYLNGI 470 ECAASAMEMS 480 AIAAHNAALL 490 AYHRWNGHTD 500 MIDQDGLYEK LKTEL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0034361	very-low-density lipoprotein particle
Molecular Function	GO:0071949	FAD binding
Molecular Function	GO:0102149	farnesylcysteine lyase activity
Molecular Function	GO:0001735	prenylcysteine oxidase activity
Biological Process	GO:0030327	prenylated protein catabolic process
Biological Process	GO:0030328	prenylcysteine catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.