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Overview

Uniprot IDQ9UHJ3
Protein NameScm-like with four MBT domains protein 1
Gene NameSFMBT1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
463 ARVYKQRKIAVVQPE
471 IAVVQPEKQVPSSRT
575 HGCGEVLKAKYKGKS
591 RATVEIVKTADRVTE
632 ENCSVLTKTKYTHYY

Function

Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis

Protein Sequence

10 MNGEQQLDAD 20 AGSGMEEVEL 30 SWEDYLEETG 40 STAVPYGSFK 50 HVDTRLQNGF 60 APGMKLEVAV 70 RTDPETYWVA 80 TVITTCEQLL 90 LLRYDGYGED 100 RRADFWCDIR 110 KADLYPIGWC 120 EQNKKTLEAP 130 EGIRDKVSDW 140 DEFLRQTLIG 150 ACSPPVPLLE 160 GLRNGRNPLD 170 LIAPGSRLEC 180 QAFQDSLSTW 190 IVTVVENIGG 200 RLKLRYEGLE 210 SSDNYEHWLY 220 YLDPFLHHVG 230 WAAQQGYELQ 240 PPSAIRHLKN 250 EAEWQEILAK 260 VKEEEEEPLP 270 SYLFKDKQVI 280 GIHTFSVNMK 290 LEAVDPWSPF 300 GISPATVVKV 310 FDEKYFLVEM 320 DDLRPENHAR 330 RSFVCHADSP 340 GIFPVQWSLK 350 NGLHISPPPG 360 YPSQDFDWAD 370 YLKQCGAEAA 380 PQRCFPPLIS 390 EHEFKENMKL 400 EAVNPILPEE 410 VCVATITAVR 420 GSYLWLQLEG 430 SKKPIPECIV 440 SVESMDIFPL 450 GWCETNGHPL 460 STPRRARVYK 470 QRKIAVVQPE 480 KQVPSSRTVH 490 EGLRNQELNS 500 TESVMINGKY 510 CCPKIYFNHR 520 CFSGPYLNKG 530 RIAELPQCVG 540 PGNCVLVLRE 550 VLTLLINAAY 560 KPSRVLRELQ 570 LDKDSVWHGC 580 GEVLKAKYKG 590 KSYRATVEIV 600 KTADRVTEFC 610 RQTCIKLECC 620 PNLFGPRMVL 630 DKCSENCSVL 640 TKTKYTHYYG 650 KKKNKRIGRP 660 PGGHSNLACA 670 LKKASKRRKR 680 RKNVFVHKKK 690 RSSASVDNTP 700 AGSPQGSGGE 710 DEDDPDEGDD 720 DSLSEGSTSE 730 QQDELQEESE 740 MSEKKSCSSS 750 PTQSEISTSL 760 PPDRQRRKRE 770 LRTFSFSDDE 780 NKPPSPKEIR 790 IEVAERLHLD 800 SNPLKWSVAD 810 VVRFIRSTDC 820 APLARIFLDQ 830 EIDGQALLLL 840 TLPTVQECMD 850 LKLGPAIKLC 860 HHIERIKFAF YEQFAN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0048635 negative regulation of muscle organ development
Biological Process GO:0007283 spermatogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.