Overview
| Uniprot ID | Q9UHK6 |
|---|
| Protein Name | Alpha-methylacyl-CoA racemase |
|---|
| Gene Name | AMACR |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 371 |
IYQLNSDKIIESNKV |
| 377 |
DKIIESNKVKASL** |
| 58 |
RSLVLDLKQPRGAAV |
| 87 |
FRRGVMEKLQLGPEI |
Function
Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:10655068, PubMed:11060359, PubMed:7649182). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:10655068, PubMed:11060359, PubMed:7649182)
Protein Sequence
10
MALQGISVVE
20
LSGLAPGPFC
30
AMVLADFGAR
40
VVRVDRPGSR
50
YDVSRLGRGK
60
RSLVLDLKQP
70
RGAAVLRRLC
80
KRSDVLLEPF
90
RRGVMEKLQL
100
GPEILQRENP
110
RLIYARLSGF
120
GQSGSFCRLA
130
GHDINYLALS
140
GVLSKIGRSG
150
ENPYAPLNLL
160
ADFAGGGLMC
170
ALGIIMALFD
180
RTRTGKGQVI
190
DANMVEGTAY
200
LSSFLWKTQK
210
LSLWEAPRGQ
220
NMLDGGAPFY
230
TTYRTADGEF
240
MAVGAIEPQF
250
YELLIKGLGL
260
KSDELPNQMS
270
MDDWPEMKKK
280
FADVFAEKTK
290
AEWCQIFDGT
300
DACVTPVLTF
310
EEVVHHDHNK
320
ERGSFITSEE
330
QDVSPRPAPL
340
LLNTPAIPSF
350
KRDPFIGEHT
360
EEILEEFGFS
370
REEIYQLNSD
380
KIIESNKVKA
SL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005782 |
peroxisomal matrix |
| Cellular Component |
GO:0005777 |
peroxisome |
| Molecular Function |
GO:0008111 |
alpha-methylacyl-CoA racemase activity |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Biological Process |
GO:0006699 |
bile acid biosynthetic process |
| Biological Process |
GO:0008206 |
bile acid metabolic process |
| Biological Process |
GO:0033540 |
fatty acid beta-oxidation using acyl-CoA oxidase |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.