Search Results
Overview
| Uniprot ID | Q9UHQ9 |
|---|---|
| Protein Name | NADH-cytochrome b5 reductase 1 |
| Gene Name | CYB5R1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 124 | YLKGVHPKFPEGGKM |
| 167 | HFNIQPNKKSPPEPR |
| 168 | FNIQPNKKSPPEPRV |
| 177 | PPEPRVAKKLGMIAG |
| 248 | FTLDHPPKDWAYSKG |
| 54 | YLLRLLDKTTVSHNT |
Function
Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor
Protein Sequence
10
MGIQTSPVLL
20
ASLGVGLVTL
30
LGLAVGSYLV
40
RRSRRPQVTL
50
LDPNEKYLLR
60
LLDKTTVSHN
70
TKRFRFALPT
80
AHHTLGLPVG
90
KHIYLSTRID
100
GSLVIRPYTP
110
VTSDEDQGYV
120
DLVIKVYLKG
130
VHPKFPEGGK
140
MSQYLDSLKV
150
GDVVEFRGPS
160
GLLTYTGKGH
170
FNIQPNKKSP
180
PEPRVAKKLG
190
MIAGGTGITP
200
MLQLIRAILK
210
VPEDPTQCFL
220
LFANQTEKDI
230
ILREDLEELQ
240
ARYPNRFKLW
250
FTLDHPPKDW
260
AYSKGFVTAD
270
MIREHLPAPG
280
DDVLVLLCGP
290
PPMVQLACHP
300
NLDKLGYSQK
MRFTY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031092 | platelet alpha granule membrane |
| Molecular Function | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H |
| Molecular Function | GO:0090524 | cytochrome-b5 reductase activity, acting on NADH |
| Molecular Function | GO:0071949 | FAD binding |
| Biological Process | GO:0015701 | bicarbonate transport |
| Biological Process | GO:0016126 | sterol biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.