Search Results

Overview

Uniprot IDQ9UHV7
Protein NameMediator of RNA polymerase II transcription subunit 13
Gene NameMED13
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
457 QQILPKHKTNEKQEK

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Protein Sequence

10 MSASFVPNGA 20 SLEDCHCNLF 30 CLADLTGIKW 40 KKYVWQGPTS 50 APILFPVTEE 60 DPILSSFSRC 70 LKADVLGVWR 80 RDQRPGRREL 90 WIFWWGEDPS 100 FADLIHHDLS 110 EEEDGVWENG 120 LSYECRTLLF 130 KAVHNLLERC 140 LMNRNFVRIG 150 KWFVKPYEKD 160 EKPINKSEHL 170 SCSFTFFLHG 180 DSNVCTSVEI 190 NQHQPVYLLS 200 EEHITLAQQS 210 NSPFQVILCP 220 FGLNGTLTGQ 230 AFKMSDSATK 240 KLIGEWKQFY 250 PISCCLKEMS 260 EEKQEDMDWE 270 DDSLAAVEVL 280 VAGVRMIYPA 290 CFVLVPQSDI 300 PTPSPVGSTH 310 CSSSCLGVHQ 320 VPASTRDPAM 330 SSVTLTPPTS 340 PEEVQTVDPQ 350 SVQKWVKFSS 360 VSDGFNSDST 370 SHHGGKIPRK 380 LANHVVDRVW 390 QECNMNRAQN 400 KRKYSASSGG 410 LCEEATAAKV 420 ASWDFVEATQ 430 RTNCSCLRHK 440 NLKSRNAGQQ 450 GQAPSLGQQQ 460 QILPKHKTNE 470 KQEKSEKPQK 480 RPLTPFHHRV 490 SVSDDVGMDA 500 DSASQRLVIS 510 APDSQVRFSN 520 IRTNDVAKTP 530 QMHGTEMANS 540 PQPPPLSPHP 550 CDVVDEGVTK 560 TPSTPQSQHF 570 YQMPTPDPLV 580 PSKPMEDRID 590 SLSQSFPPQY 600 QEAVEPTVYV 610 GTAVNLEEDE 620 ANIAWKYYKF 630 PKKKDVEFLP 640 PQLPSDKFKD 650 DPVGPFGQES 660 VTSVTELMVQ 670 CKKPLKVSDE 680 LVQQYQIKNQ 690 CLSAIASDAE 700 QEPKIDPYAF 710 VEGDEEFLFP 720 DKKDRQNSER 730 EAGKKHKVED 740 GTSSVTVLSH 750 EEDAMSLFSP 760 SIKQDAPRPT 770 SHARPPSTSL 780 IYDSDLAVSY 790 TDLDNLFNSD 800 EDELTPGSKK 810 SANGSDDKAS 820 CKESKTGNLD 830 PLSCISTADL 840 HKMYPTPPSL 850 EQHIMGFSPM 860 NMNNKEYGSM 870 DTTPGGTVLE 880 GNSSSIGAQF 890 KIEVDEGFCS 900 PKPSEIKDFS 910 YVYKPENCQI 920 LVGCSMFAPL 930 KTLPSQYLPP 940 IKLPEECIYR 950 QSWTVGKLEL 960 LSSGPSMPFI 970 KEGDGSNMDQ 980 EYGTAYTPQT 990 HTSFGMPPSS 1000 APPSNSGAGI 1010 LPSPSTPRFP 1020 TPRTPRTPRT 1030 PRGAGGPASA 1040 QGSVKYENSD 1050 LYSPASTPST 1060 CRPLNSVEPA 1070 TVPSIPEAHS 1080 LYVNLILSES 1090 VMNLFKDCNF 1100 DSCCICVCNM 1110 NIKGADVGVY 1120 IPDPTQEAQY 1130 RCTCGFSAVM 1140 NRKFGNNSGL 1150 FLEDELDIIG 1160 RNTDCGKEAE 1170 KRFEALRATS 1180 AEHVNGGLKE 1190 SEKLSDDLIL 1200 LLQDQCTNLF 1210 SPFGAADQDP 1220 FPKSGVISNW 1230 VRVEERDCCN 1240 DCYLALEHGR 1250 QFMDNMSGGK 1260 VDEALVKSSC 1270 LHPWSKRNDV 1280 SMQCSQDILR 1290 MLLSLQPVLQ 1300 DAIQKKRTVR 1310 PWGVQGPLTW 1320 QQFHKMAGRG 1330 SYGTDESPEP 1340 LPIPTFLLGY 1350 DYDYLVLSPF 1360 ALPYWERLML 1370 EPYGSQRDIA 1380 YVVLCPENEA 1390 LLNGAKSFFR 1400 DLTAIYESCR 1410 LGQHRPVSRL 1420 LTDGIMRVGS 1430 TASKKLSEKL 1440 VAEWFSQAAD 1450 GNNEAFSKLK 1460 LYAQVCRYDL 1470 GPYLASLPLD 1480 SSLLSQPNLV 1490 APTSQSLITP 1500 PQMTNTGNAN 1510 TPSATLASAA 1520 SSTMTVTSGV 1530 AISTSVATAN 1540 STLTTASTSS 1550 SSSSNLNSGV 1560 SSNKLPSFPP 1570 FGSMNSNAAG 1580 SMSTQANTVQ 1590 SGQLGGQQTS 1600 ALQTAGISGE 1610 SSSLPTQPHP 1620 DVSESTMDRD 1630 KVGIPTDGDS 1640 HAVTYPPAIV 1650 VYIIDPFTYE 1660 NTDESTNSSS 1670 VWTLGLLRCF 1680 LEMVQTLPPH 1690 IKSTVSVQII 1700 PCQYLLQPVK 1710 HEDREIYPQH 1720 LKSLAFSAFT 1730 QCRRPLPTST 1740 NVKTLTGFGP 1750 GLAMETALRS 1760 PDRPECIRLY 1770 APPFILAPVK 1780 DKQTELGETF 1790 GEAGQKYNVL 1800 FVGYCLSHDQ 1810 RWILASCTDL 1820 YGELLETCII 1830 NIDVPNRARR 1840 KKSSARKFGL 1850 QKLWEWCLGL 1860 VQMSSLPWRV 1870 VIGRLGRIGH 1880 GELKDWSCLL 1890 SRRNLQSLSK 1900 RLKDMCRMCG 1910 ISAADSPSIL 1920 SACLVAMEPQ 1930 GSFVIMPDSV 1940 STGSVFGRST 1950 TLNMQTSQLN 1960 TPQDTSCTHI 1970 LVFPTSASVQ 1980 VASATYTTEN 1990 LDLAFNPNND 2000 GADGMGIFDL 2010 LDTGDDLDPD 2020 IINILPASPT 2030 GSPVHSPGSH 2040 YPHGGDAGKG 2050 QSTDRLLSTE 2060 PHEEVPNILQ 2070 QPLALGYFVS 2080 TAKAGPLPDW 2090 FWSACPQAQY 2100 QCPLFLKASL 2110 HLHVPSVQSD 2120 ELLHSKHSHP 2130 LDSNQTSDVL 2140 RFVLEQYNAL 2150 SWLTCDPATQ 2160 DRRSCLPIHF 2170 VVLNQLYNFI MNML

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016592 mediator complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0042809 nuclear vitamin D receptor binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Biological Process GO:0070328 triglyceride homeostasis

Reference

PMID: N/A