Search Results
Overview
| Uniprot ID | Q9UI09 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 |
| Gene Name | NDUFA12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | TDDPPTTKPLTARKF |
| 8 | MELVQVLKRGLQQIT |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Protein Sequence
10
MELVQVLKRG
20
LQQITGHGGL
30
RGYLRVFFRT
40
NDAKVGTLVG
50
EDKYGNKYYE
60
DNKQFFGRHR
70
WVVYTTEMNG
80
KNTFWDVDGS
90
MVPPEWHRWL
100
HSMTDDPPTT
110
KPLTARKFIW
120
TNHKFNVTGT
130
PEQYVPYSTT
140
RKKIQEWIPP
STPYK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0042775 | mitochondrial ATP synthesis coupled electron transport |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.