Search Results

Overview

Uniprot IDQ9UI17
Protein NameDimethylglycine dehydrogenase, mitochondrial
Gene NameDMGDH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 HPGINLKKIHYDSIK
223 PAPVTSLKARSDGTW
360 MEMVPVLKKADIINV
37 CGREGEEKPPLSAET
543 PFGKFNIKGQDSIRL
663 FLQTKSLKVSNIPVT

Function

Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro

Protein Sequence

10 MLRPGAQLLR 20 GLLLRSCPLQ 30 GSPGRPRSVC 40 GREGEEKPPL 50 SAETQWKDRA 60 ETVIIGGGCV 70 GVSLAYHLAK 80 AGMKDVVLLE 90 KSELTAGSTW 100 HAAGLTTYFH 110 PGINLKKIHY 120 DSIKLYEKLE 130 EETGQVVGFH 140 QPGSIRLATT 150 PVRVDEFKYQ 160 MTRTGWHATE 170 QYLIEPEKIQ 180 EMFPLLNMNK 190 VLAGLYNPGD 200 GHIDPYSLTM 210 ALAAGARKCG 220 ALLKYPAPVT 230 SLKARSDGTW 240 DVETPQGSMR 250 ANRIVNAAGF 260 WAREVGKMIG 270 LEHPLIPVQH 280 QYVVTSTISE 290 VKALKRELPV 300 LRDLEGSYYL 310 RQERDGLLFG 320 PYESQEKMKV 330 QDSWVTNGVP 340 PGFGKELFES 350 DLDRIMEHIK 360 AAMEMVPVLK 370 KADIINVVNG 380 PITYSPDILP 390 MVGPHQGVRN 400 YWVAIGFGYG 410 IIHAGGVGKY 420 LSDWILHGEP 430 PFDLIELDPN 440 RYGKWTTTQY 450 TEAKARESYG 460 FNNIVGYPKE 470 ERFAGRPTQR 480 VSGLYQRLES 490 KCSMGFHAGW 500 EQPHWFYKPG 510 QDTQYRPSFR 520 RTNWFEPVGS 530 EYKQVMQRVA 540 VTDLSPFGKF 550 NIKGQDSIRL 560 LDHLFANVIP 570 KVGFTNISHM 580 LTPKGRVYAE 590 LTVSHQSPGE 600 FLLITGSGSE 610 LHDLRWIEEE 620 AVKGGYDVEI 630 KNITDELGVL 640 GVAGPQARKV 650 LQKLTSEDLS 660 DDVFKFLQTK 670 SLKVSNIPVT 680 AIRISYTGEL 690 GWELYHRRED 700 SVALYDAIMN 710 AGQEEGIDNF 720 GTYAMNALRL 730 EKAFRAWGLE 740 MNCDTNPLEA 750 GLEYFVKLNK 760 PADFIGKQAL 770 KQIKAKGLKR 780 RLVCLTLATD 790 DVDPEGNESI 800 WYNGKVVGNT 810 TSGSYSYSIQ 820 KSLAFAYVPV 830 QLSEVGQQVE 840 VELLGKNYPA 850 VIIQEPLVLT 860 EPTRNRLQKK GGKDKT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0047865 dimethylglycine dehydrogenase activity
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006579 amino-acid betaine catabolic process
Biological Process GO:0042426 choline catabolic process
Biological Process GO:0019695 choline metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.