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Overview

Uniprot IDQ9UI26
Protein NameImportin-11
Gene NameIPO11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
337 NYAYKPSKNFEDSSP

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity)

Protein Sequence

10 MDLNSASTVV 20 LQVLTQATSQ 30 DTAVLKPAEE 40 QLKQWETQPG 50 FYSVLLNIFT 60 NHTLDINVRW 70 LAVLYFKHGI 80 DRYWRRVAPH 90 ALSEEEKTTL 100 RAGLITNFNE 110 PINQIATQIA 120 VLIAKVARLD 130 CPRQWPELIP 140 TLIESVKVQD 150 DLRQHRALLT 160 FYHVTKTLAS 170 KRLAADRKLF 180 YDLASGIYNF 190 ACSLWNHHTD 200 TFLQEVSSGN 210 EAAILSSLER 220 TLLSLKVLRK 230 LTVNGFVEPH 240 KNMEVMGFLH 250 GIFERLKQFL 260 ECSRSIGTDN 270 VCRDRLEKTI 280 ILFTKVLLDF 290 LDQHPFSFTP 300 LIQRSLEFSV 310 SYVFTEVGEG 320 VTFERFIVQC 330 MNLIKMIVKN 340 YAYKPSKNFE 350 DSSPETLEAH 360 KIKMAFFTYP 370 TLTEICRRLV 380 SHYFLLTEEE 390 LTMWEEDPEG 400 FTVEETGGDS 410 WKYSLRPCTE 420 VLFIDIFHEY 430 NQTLTPVLLE 440 MMQTLQGPTN 450 VEDMNALLIK 460 DAVYNAVGLA 470 AYELFDSVDF 480 DQWFKNQLLP 490 ELQVIHNRYK 500 PLRRRVIWLI 510 GQWISVKFKS 520 DLRPMLYEAI 530 CNLLQDQDLV 540 VRIETATTLK 550 LTVDDFEFRT 560 DQFLPYLETM 570 FTLLFQLLQQ 580 VTECDTKMHV 590 LHVLSCVIER 600 VNMQIRPYVG 610 CLVQYLPLLW 620 KQSEEHNMLR 630 CAILTTLIHL 640 VQGLGADSKN 650 LYPFLLPVIQ 660 LSTDVSQPPH 670 VYLLEDGLEL 680 WLVTLENSPC 690 ITPELLRIFQ 700 NMSPLLELSS 710 ENLRTCFKII 720 NGYIFLSSTE 730 FLQTYAVGLC 740 QSFCELLKEI 750 TTEGQVQVLK 760 VVENALKVNP 770 ILGPQMFQPI 780 LPYVFKGIIE 790 GERYPVVMST 800 YLGVMGRVLL 810 QNTSFFSSLL 820 NEMAHKFNQE 830 MDQLLGNMIE 840 MWVDRMDNIT 850 QPERRKLSAL 860 ALLSLLPSDN 870 SVIQDKFCGI 880 INISVEGLHD 890 VMTEDPETGT 900 YKDCMLMSHL 910 EEPKVTEDEE 920 PPTEQDKRKK 930 MLALKDPVHT 940 VSLQQFIYEK 950 LKAQQEMLGE 960 QGFQSLMETV 970 DTEIVTQLQE FLQGF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0061608 nuclear import signal receptor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006606 protein import into nucleus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.