Search Results

Overview

Uniprot IDQ9UI33
Protein NameSodium channel protein type 11 subunit alpha
Gene NameSCN11A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
419 AEIEAKEKMFQEAQQ

Function

Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:10580103, PubMed:12384689, PubMed:24036948, PubMed:24776970, PubMed:25791876, PubMed:26645915). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed:24036948, PubMed:24776970, PubMed:25791876, PubMed:26645915). Also involved in rapid BDNF-evoked neuronal depolarization (PubMed:12384689)

Protein Sequence

10 MDDRCYPVIF 20 PDERNFRPFT 30 SDSLAAIEKR 40 IAIQKEKKKS 50 KDQTGEVPQP 60 RPQLDLKASR 70 KLPKLYGDIP 80 RELIGKPLED 90 LDPFYRNHKT 100 FMVLNRKRTI 110 YRFSAKHALF 120 IFGPFNSIRS 130 LAIRVSVHSL 140 FSMFIIGTVI 150 INCVFMATGP 160 AKNSNSNNTD 170 IAECVFTGIY 180 IFEALIKILA 190 RGFILDEFSF 200 LRDPWNWLDS 210 IVIGIAIVSY 220 IPGITIKLLP 230 LRTFRVFRAL 240 KAISVVSRLK 250 VIVGALLRSV 260 KKLVNVIILT 270 FFCLSIFALV 280 GQQLFMGSLN 290 LKCISRDCKN 300 ISNPEAYDHC 310 FEKKENSPEF 320 KMCGIWMGNS 330 ACSIQYECKH 340 TKINPDYNYT 350 NFDNFGWSFL 360 AMFRLMTQDS 370 WEKLYQQTLR 380 TTGLYSVFFF 390 IVVIFLGSFY 400 LINLTLAVVT 410 MAYEEQNKNV 420 AAEIEAKEKM 430 FQEAQQLLKE 440 EKEALVAMGI 450 DRSSLTSLET 460 SYFTPKKRKL 470 FGNKKRKSFF 480 LRESGKDQPP 490 GSDSDEDCQK 500 KPQLLEQTKR 510 LSQNLSLDHF 520 DEHGDPLQRQ 530 RALSAVSILT 540 ITMKEQEKSQ 550 EPCLPCGENL 560 ASKYLVWNCC 570 PQWLCVKKVL 580 RTVMTDPFTE 590 LAITICIIIN 600 TVFLAMEHHK 610 MEASFEKMLN 620 IGNLVFTSIF 630 IAEMCLKIIA 640 LDPYHYFRRG 650 WNIFDSIVAL 660 LSFADVMNCV 670 LQKRSWPFLR 680 SFRVLRVFKL 690 AKSWPTLNTL 700 IKIIGNSVGA 710 LGSLTVVLVI 720 VIFIFSVVGM 730 QLFGRSFNSQ 740 KSPKLCNPTG 750 PTVSCLRHWH 760 MGDFWHSFLV 770 VFRILCGEWI 780 ENMWECMQEA 790 NASSSLCVIV 800 FILITVIGKL 810 VVLNLFIALL 820 LNSFSNEERN 830 GNLEGEARKT 840 KVQLALDRFR 850 RAFCFVRHTL 860 EHFCHKWCRK 870 QNLPQQKEVA 880 GGCAAQSKDI 890 IPLVMEMKRG 900 SETQEELGIL 910 TSVPKTLGVR 920 HDWTWLAPLA 930 EEEDDVEFSG 940 EDNAQRITQP 950 EPEQQAYELH 960 QENKKPTSQR 970 VQSVEIDMFS 980 EDEPHLTIQD 990 PRKKSDVTSI 1000 LSECSTIDLQ 1010 DGFGWLPEMV 1020 PKKQPERCLP 1030 KGFGCCFPCC 1040 SVDKRKPPWV 1050 IWWNLRKTCY 1060 QIVKHSWFES 1070 FIIFVILLSS 1080 GALIFEDVHL 1090 ENQPKIQELL 1100 NCTDIIFTHI 1110 FILEMVLKWV 1120 AFGFGKYFTS 1130 AWCCLDFIIV 1140 IVSVTTLINL 1150 MELKSFRTLR 1160 ALRPLRALSQ 1170 FEGMKVVVNA 1180 LIGAIPAILN 1190 VLLVCLIFWL 1200 VFCILGVYFF 1210 SGKFGKCING 1220 TDSVINYTII 1230 TNKSQCESGN 1240 FSWINQKVNF 1250 DNVGNAYLAL 1260 LQVATFKGWM 1270 DIIYAAVDST 1280 EKEQQPEFES 1290 NSLGYIYFVV 1300 FIIFGSFFTL 1310 NLFIGVIIDN 1320 FNQQQKKLGG 1330 QDIFMTEEQK 1340 KYYNAMKKLG 1350 SKKPQKPIPR 1360 PLNKCQGLVF 1370 DIVTSQIFDI 1380 IIISLIILNM 1390 ISMMAESYNQ 1400 PKAMKSILDH 1410 LNWVFVVIFT 1420 LECLIKIFAL 1430 RQYYFTNGWN 1440 LFDCVVVLLS 1450 IVSTMISTLE 1460 NQEHIPFPPT 1470 LFRIVRLARI 1480 GRILRLVRAA 1490 RGIRTLLFAL 1500 MMSLPSLFNI 1510 GLLLFLIMFI 1520 YAILGMNWFS 1530 KVNPESGIDD 1540 IFNFKTFASS 1550 MLCLFQISTS 1560 AGWDSLLSPM 1570 LRSKESCNSS 1580 SENCHLPGIA 1590 TSYFVSYIII 1600 SFLIVVNMYI 1610 AVILENFNTA 1620 TEESEDPLGE 1630 DDFDIFYEVW 1640 EKFDPEATQF 1650 IKYSALSDFA 1660 DALPEPLRVA 1670 KPNKYQFLVM 1680 DLPMVSEDRL 1690 HCMDILFAFT 1700 ARVLGGSDGL 1710 DSMKAMMEEK 1720 FMEANPLKKL 1730 YEPIVTTTKR 1740 KEEERGAAII 1750 QKAFRKYMMK 1760 VTKGDQGDQN 1770 DLENGPHSPL 1780 QTLCNGDLSS 1790 FGVAKGKVHC D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0044295 axonal growth cone
Cellular Component GO:0044299 C-fiber
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001518 voltage-gated sodium channel complex
Molecular Function GO:0005248 voltage-gated sodium channel activity
Biological Process GO:0099610 action potential initiation
Biological Process GO:0002526 acute inflammatory response
Biological Process GO:0060840 artery development
Biological Process GO:0007409 axonogenesis
Biological Process GO:0061367 behavioral response to acetic acid induced pain
Biological Process GO:0061368 behavioral response to formalin induced pain
Biological Process GO:1990408 calcitonin gene-related peptide receptor signaling pathway
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0141156 cAMP/PKA signal transduction
Biological Process GO:0086002 cardiac muscle cell action potential involved in contraction
Biological Process GO:0048870 cell motility
Biological Process GO:0070417 cellular response to cold
Biological Process GO:0002544 chronic inflammatory response
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0050965 detection of temperature stimulus involved in sensory perception of pain
Biological Process GO:0043303 mast cell degranulation
Biological Process GO:0086010 membrane depolarization during action potential
Biological Process GO:0060073 micturition
Biological Process GO:0019228 neuronal action potential
Biological Process GO:0060004 reflex
Biological Process GO:0010996 response to auditory stimulus
Biological Process GO:0009408 response to heat
Biological Process GO:0009644 response to high light intensity
Biological Process GO:0071731 response to nitric oxide
Biological Process GO:0034695 response to prostaglandin E
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0160025 sensory perception of itch
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0060538 skeletal muscle organ development
Biological Process GO:1990770 small intestine smooth muscle contraction
Biological Process GO:0035725 sodium ion transmembrane transport
Biological Process GO:0040040 thermosensory behavior
Biological Process GO:0001966 thigmotaxis

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.