Search Results
Overview
| Uniprot ID | Q9UI40 |
|---|---|
| Protein Name | Sodium/potassium/calcium exchanger 2 |
| Gene Name | SLC24A2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 301 | INRNKVVKVTAPEAQ |
Function
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10662833, PubMed:26631410). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (By similarity)
Protein Sequence
10
MDLQQSTTIT
20
SLEKWCLDES
30
LSGCRRHYSV
40
KKKLKLIRVL
50
GLFMGLVAIS
60
TVSFSISAFS
70
ETDTQSTGEA
80
SVVSGPRVAQ
90
GYHQRTLLDL
100
NDKILDYTPQ
110
PPLSKEGESE
120
NSTDHAQGDY
130
PKDIFSLEER
140
RKGAIILHVI
150
GMIYMFIALA
160
IVCDEFFVPS
170
LTVITEKLGI
180
SDDVAGATFM
190
AAGGSAPELF
200
TSLIGVFIAH
210
SNVGIGTIVG
220
SAVFNILFVI
230
GMCALFSREI
240
LNLTWWPLFR
250
DVSFYIVDLI
260
MLIIFFLDNV
270
IMWWESLLLL
280
TAYFCYVVFM
290
KFNVQVEKWV
300
KQMINRNKVV
310
KVTAPEAQAK
320
PSAARDKDEP
330
TLPAKPRLQR
340
GGSSASLHNS
350
LMRNSIFQLM
360
IHTLDPLAEE
370
LGSYGKLKYY
380
DTMTEEGRFR
390
EKASILHKIA
400
KKKCHVDENE
410
RQNGAANHVE
420
KIELPNSTST
430
DVEMTPSSDA
440
SEPVQNGNLS
450
HNIEGAEAQT
460
ADEEEDQPLS
470
LAWPSETRKQ
480
VTFLIVFPIV
490
FPLWITLPDV
500
RKPSSRKFFP
510
ITFFGSITWI
520
AVFSYLMVWW
530
AHQVGETIGI
540
SEEIMGLTIL
550
AAGTSIPDLI
560
TSVIVARKGL
570
GDMAVSSSVG
580
SNIFDITVGL
590
PLPWLLYTVI
600
HRFQPVAVSS
610
NGLFCAIVLL
620
FIMLLFVILS
630
IALCKWRMNK
640
ILGFIMFGLY
650
FVFLVVSVLL
660
EDRILTCPVS
I
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0005262 | calcium channel activity |
| Molecular Function | GO:0008273 | calcium, potassium:sodium antiporter activity |
| Molecular Function | GO:0015293 | symporter activity |
| Biological Process | GO:0070509 | calcium ion import |
| Biological Process | GO:0098703 | calcium ion import across plasma membrane |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0071486 | cellular response to high light intensity |
| Biological Process | GO:0036368 | cone photoresponse recovery |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0060292 | long-term synaptic depression |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:0007602 | phototransduction |
| Biological Process | GO:0071805 | potassium ion transmembrane transport |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
Reference
PMID: N/A