Overview
| Uniprot ID | Q9UID3 |
|---|
| Protein Name | Vacuolar protein sorting-associated protein 51 homolog |
|---|
| Gene Name | VPS51 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 124 |
SATDTIRKMKNDFRK |
| 126 |
TDTIRKMKNDFRKME |
Function
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061)
Protein Sequence
10
MAAAAAAGPS
20
PGSGPGDSPE
30
GPEGEAPERR
40
RKAHGMLKLY
50
YGLSEGEAAG
60
RPAGPDPLDP
70
TDLNGAHFDP
80
EVYLDKLRRE
90
CPLAQLMDSE
100
TDMVRQIRAL
110
DSDMQTLVYE
120
NYNKFISATD
130
TIRKMKNDFR
140
KMEDEMDRLA
150
TNMAVITDFS
160
ARISATLQDR
170
HERITKLAGV
180
HALLRKLQFL
190
FELPSRLTKC
200
VELGAYGQAV
210
RYQGRAQAVL
220
QQYQHLPSFR
230
AIQDDCQVIT
240
ARLAQQLRQR
250
FREGGSGAPE
260
QAECVELLLA
270
LGEPAEELCE
280
EFLAHARGRL
290
EKELRNLEAE
300
LGPSPPAPDV
310
LEFTDHGGSG
320
FVGGLCQVAA
330
AYQELFAAQG
340
PAGAEKLAAF
350
ARQLGSRYFA
360
LVERRLAQEQ
370
GGGDNSLLVR
380
ALDRFHRRLR
390
APGALLAAAG
400
LADAATEIVE
410
RVARERLGHH
420
LQGLRAAFLG
430
CLTDVRQALA
440
APRVAGKEGP
450
GLAELLANVA
460
SSILSHIKAS
470
LAAVHLFTAK
480
EVSFSNKPYF
490
RGEFCSQGVR
500
EGLIVGFVHS
510
MCQTAQSFCD
520
SPGEKGGATP
530
PALLLLLSRL
540
CLDYETATIS
550
YILTLTDEQF
560
LVQDQFPVTP
570
VSTLCAEARE
580
TARRLLTHYV
590
KVQGLVISQM
600
LRKSVETRDW
610
LSTLEPRNVR
620
AVMKRVVEDT
630
TAIDVQVGLL
640
YEEGVRKAQS
650
SDSSKRTFSV
660
YSSSRQQGRY
670
APSYTPSAPM
680
DTNLLSNIQK
690
LFSERIDVFS
700
PVEFNKVSVL
710
TGIIKISLKT
720
LLECVRLRTF
730
GRFGLQQVQV
740
DCHFLQLYLW
750
RFVADEELVH
760
LLLDEVVASA
770
ALRCPDPVPM
780
EPSVVEVICE
RG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:1990745 |
EARP complex |
| Cellular Component |
GO:0000938 |
GARP complex |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Cellular Component |
GO:0032588 |
trans-Golgi network membrane |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0048854 |
brain morphogenesis |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0048193 |
Golgi vesicle transport |
| Biological Process |
GO:0007041 |
lysosomal transport |
| Biological Process |
GO:0006605 |
protein targeting |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0042147 |
retrograde transport, endosome to Golgi |
| Biological Process |
GO:0090119 |
vesicle-mediated cholesterol transport |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.