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Overview

Uniprot IDQ9UIG0
Protein NameTyrosine-protein kinase BAZ1B
Gene NameBAZ1B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1121 APKQKRRKLQSEDSA
1335 DELVLQTKRSSRRQS
200 RARRSPRKLPTSLKK
206 RKLPTSLKKGERKWA
322 RKPSKKSKTDNSSLS
352 SLSGSPLKVKNSKNS
354 SGSPLKVKNSKNSKS
386 HTNFHIPKKGPPAKK
387 TNFHIPKKGPPAKKP
416 KGILNGQKSTGNSKS
843 EDMISAVKSRRLLAI
942 YRFNHHCKDHTVSGD

Function

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136)

Protein Sequence

10 MAPLLGRKPF 20 PLVKPLPGEE 30 PLFTIPHTQE 40 AFRTREEYEA 50 RLERYSERIW 60 TCKSTGSSQL 70 THKEAWEEEQ 80 EVAELLKEEF 90 PAWYEKLVLE 100 MVHHNTASLE 110 KLVDTAWLEI 120 MTKYAVGEEC 130 DFEVGKEKML 140 KVKIVKIHPL 150 EKVDEEATEK 160 KSDGACDSPS 170 SDKENSSQIA 180 QDHQKKETVV 190 KEDEGRRESI 200 NDRARRSPRK 210 LPTSLKKGER 220 KWAPPKFLPH 230 KYDVKLQNED 240 KIISNVPADS 250 LIRTERPPNK 260 EIVRYFIRHN 270 ALRAGTGENA 280 PWVVEDELVK 290 KYSLPSKFSD 300 FLLDPYKYMT 310 LNPSTKRKNT 320 GSPDRKPSKK 330 SKTDNSSLSS 340 PLNPKLWCHV 350 HLKKSLSGSP 360 LKVKNSKNSK 370 SPEEHLEEMM 380 KMMSPNKLHT 390 NFHIPKKGPP 400 AKKPGKHSDK 410 PLKAKGRSKG 420 ILNGQKSTGN 430 SKSPKKGLKT 440 PKTKMKQMTL 450 LDMAKGTQKM 460 TRAPRNSGGT 470 PRTSSKPHKH 480 LPPAALHLIA 490 YYKENKDRED 500 KRSALSCVIS 510 KTARLLSSED 520 RARLPEELRS 530 LVQKRYELLE 540 HKKRWASMSE 550 EQRKEYLKKK 560 REELKKKLKE 570 KAKERREKEM 580 LERLEKQKRY 590 EDQELTGKNL 600 PAFRLVDTPE 610 GLPNTLFGDV 620 AMVVEFLSCY 630 SGLLLPDAQY 640 PITAVSLMEA 650 LSADKGGFLY 660 LNRVLVILLQ 670 TLLQDEIAED 680 YGELGMKLSE 690 IPLTLHSVSE 700 LVRLCLRRSD 710 VQEESEGSDT 720 DDNKDSAAFE 730 DNEVQDEFLE 740 KLETSEFFEL 750 TSEEKLQILT 760 ALCHRILMTY 770 SVQDHMETRQ 780 QMSAELWKER 790 LAVLKEENDK 800 KRAEKQKRKE 810 MEAKNKENGK 820 VENGLGKTDR 830 KKEIVKFEPQ 840 VDTEAEDMIS 850 AVKSRRLLAI 860 QAKKEREIQE 870 REMKVKLERQ 880 AEEERIRKHK 890 AAAEKAFQEG 900 IAKAKLVMRR 910 TPIGTDRNHN 920 RYWLFSDEVP 930 GLFIEKGWVH 940 DSIDYRFNHH 950 CKDHTVSGDE 960 DYCPRSKKAN 970 LGKNASMNTQ 980 HGTATEVAVE 990 TTTPKQGQNL 1000 WFLCDSQKEL 1010 DELLNCLHPQ 1020 GIRESQLKER 1030 LEKRYQDIIH 1040 SIHLARKPNL 1050 GLKSCDGNQE 1060 LLNFLRSDLI 1070 EVATRLQKGG 1080 LGYVEETSEF 1090 EARVISLEKL 1100 KDFGECVIAL 1110 QASVIKKFLQ 1120 GFMAPKQKRR 1130 KLQSEDSAKT 1140 EEVDEEKKMV 1150 EEAKVASALE 1160 KWKTAIREAQ 1170 TFSRMHVLLG 1180 MLDACIKWDM 1190 SAENARCKVC 1200 RKKGEDDKLI 1210 LCDECNKAFH 1220 LFCLRPALYE 1230 VPDGEWQCPA 1240 CQPATARRNS 1250 RGRNYTEESA 1260 SEDSEDDESD 1270 EEEEEEEEEE 1280 EEEDYEVAGL 1290 RLRPRKTIRG 1300 KHSVIPPAAR 1310 SGRRPGKKPH 1320 STRRSQPKAP 1330 PVDDAEVDEL 1340 VLQTKRSSRR 1350 QSLELQKCEE 1360 ILHKIVKYRF 1370 SWPFREPVTR 1380 DEAEDYYDVI 1390 THPMDFQTVQ 1400 NKCSCGSYRS 1410 VQEFLTDMKQ 1420 VFTNAEVYNC 1430 RGSHVLSCMV 1440 KTEQCLVALL 1450 HKHLPGHPYV 1460 RRKRKKFPDR 1470 LAEDEGDSEP 1480 EAVGQSRGRR QKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000793 condensed chromosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005721 pericentric heterochromatin
Cellular Component GO:0090535 WICH complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140801 histone H2AXY142 kinase activity
Molecular Function GO:0035173 histone kinase activity
Molecular Function GO:0004715 non-membrane spanning protein tyrosine kinase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1905213 negative regulation of mitotic chromosome condensation
Biological Process GO:0045943 positive regulation of transcription by RNA polymerase I
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045945 positive regulation of transcription by RNA polymerase III
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.